Physician Data Query

Last uploaded: January 31, 2024
Preferred Name

proteolytic enzymes

Synonyms
Definitions

Enzymes produced and secreted by the pancreas which aid in the proteolysis of proteins in the digestive tract. Pancreatic proteolytic enzymes include trypsin, chymotrypsin and carboxypeptidase; these enzymes are secreted as zymogens, inactive precursors of the enzymes, and are activated in the lumen of the digestive canal. Another proteolytic enzyme, enteropeptidase, is associated with the brush border of enterocytes; this enzyme catalyses the conversion of trypsinogen into trypsin which, in turn, can activate a number of other pancreatic zymogens. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C38728" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C38728" NCI Thesaurus)

ID

http://purl.bioontology.org/ontology/PDQ/CDR0000043492

cui

C0030940

Date last modified

2006-09-11

definition

Enzymes produced and secreted by the pancreas which aid in the proteolysis of proteins in the digestive tract. Pancreatic proteolytic enzymes include trypsin, chymotrypsin and carboxypeptidase; these enzymes are secreted as zymogens, inactive precursors of the enzymes, and are activated in the lumen of the digestive canal. Another proteolytic enzyme, enteropeptidase, is associated with the brush border of enterocytes; this enzyme catalyses the conversion of trypsinogen into trypsin which, in turn, can activate a number of other pancreatic zymogens. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C38728" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C38728" NCI Thesaurus)

Legacy PDQ ID

8722

NCI ID

C38728

notation

CDR0000043492

ORIG STY

Drug/agent

prefLabel

proteolytic enzymes

tui

T116

T126

T121

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