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| Preferred Name | temsirolimus | |
| Synonyms |
CCI-779 Rapamycin Analog cell cycle inhibitor 779 Torisel 42-(3-hydroxy-2-(hydroxymethyl)-2-methylpropanoate)rapamycin rapamycin analog CCI-779 CCI-779 |
|
| Definitions |
An ester analog of rapamycin. Temsirolimus binds to and inhibits the mammalian target of rapamycin (mTOR), resulting in decreased expression of mRNAs necessary for cell cycle progression and arresting cells in the G1 phase of the cell cycle. mTOR is a serine/threonine kinase which plays a role in the PI3K/AKT pathway that is upregulated in some tumors. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1844" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C1844" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000043369 |
|
| altLabel |
CCI-779 Rapamycin Analog cell cycle inhibitor 779 Torisel 42-(3-hydroxy-2-(hydroxymethyl)-2-methylpropanoate)rapamycin rapamycin analog CCI-779 CCI-779
|
|
| CAS Registry |
162635-04-3
|
|
| Component of |
http://purl.bioontology.org/ontology/PDQ/CDR0000433189 http://purl.bioontology.org/ontology/PDQ/CDR0000434598 http://purl.bioontology.org/ontology/PDQ/CDR0000410685 http://purl.bioontology.org/ontology/PDQ/CDR0000430566 http://purl.bioontology.org/ontology/PDQ/CDR0000405966 http://purl.bioontology.org/ontology/PDQ/CDR0000257376 |
|
| cui |
C0796512 C1951646 C1707080
|
|
| Date last modified |
2007-06-05
|
|
| definition |
An ester analog of rapamycin. Temsirolimus binds to and inhibits the mammalian target of rapamycin (mTOR), resulting in decreased expression of mRNAs necessary for cell cycle progression and arresting cells in the G1 phase of the cell cycle. mTOR is a serine/threonine kinase which plays a role in the PI3K/AKT pathway that is upregulated in some tumors. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1844" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C1844" NCI Thesaurus)
|
|
| IND Code |
61010
|
|
| Legacy PDQ ID |
7917
|
|
| LT |
TRD
|
|
| NCI ID |
C1844
|
|
| notation |
CDR0000043369
|
|
| NSC Code |
683864
|
|
| ORIG STY |
Drug/agent
|
|
| prefLabel |
temsirolimus
|
|
| tui |
T109 T121
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