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| Preferred Name | pegylated interferon alfa | |
| Synonyms |
PEG-interferon alfa PEG-IFN-a PEG-IFNA |
|
| Definitions |
A covalent conjugate of recombinant interferon alpha and polyethylene glycol (PEG), used as an antiviral and antineoplastic agent. The biological activity of this agent is derived from its interferon alpha protein moiety. Interferons alfa bind to specific cell-surface receptors, leading to the transcription and translation of genes whose protein products mediate antiviral, antiproliferative, anticancer, and immune-modulating effects. The PEG moiety lowers the clearance of interferon alpha, thereby extending the duration of its therapeutic effects, but may also reduce interferon-mediated stimulation of an immune response. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C2491" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C2491" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000043151 |
|
| altLabel |
PEG-interferon alfa PEG-IFN-a PEG-IFNA
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| Component of | ||
| cui |
C0907160
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| Date last modified |
2006-09-08
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|
| definition |
A covalent conjugate of recombinant interferon alpha and polyethylene glycol (PEG), used as an antiviral and antineoplastic agent. The biological activity of this agent is derived from its interferon alpha protein moiety. Interferons alfa bind to specific cell-surface receptors, leading to the transcription and translation of genes whose protein products mediate antiviral, antiproliferative, anticancer, and immune-modulating effects. The PEG moiety lowers the clearance of interferon alpha, thereby extending the duration of its therapeutic effects, but may also reduce interferon-mediated stimulation of an immune response. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C2491" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C2491" NCI Thesaurus)
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| Legacy PDQ ID |
7593
|
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| NCI ID |
C2491
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|
| notation |
CDR0000043151
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| ORIG STY |
Drug/agent
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|
| prefLabel |
pegylated interferon alfa
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|
| tui |
T109 T129 T121
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| Delete | Subject | Author | Type | Created |
|---|---|---|---|---|
| No notes to display |
| Mapping To | Ontology | Source |
|---|---|---|
| http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2491 | NCIT | LOOM |
| http://purl.obolibrary.org/obo/NCIT_C2491 | BERO | LOOM |
| http://sbmi.uth.tmc.edu/ontology/ochv#48970 | OCHV | LOOM |
| http://sbmi.uth.tmc.edu/ontology/ochv#C0796333 | OCHV | LOOM |