Physician Data Query

Last uploaded: August 27, 2019
Id http://purl.bioontology.org/ontology/PDQ/CDR0000043130
http://purl.bioontology.org/ontology/PDQ/CDR0000043130
Preferred Name

fluorouracil injection

Definitions
An antimetabolite fluoropyrimidine analog of the nucleoside pyrimidine with antineoplastic activity. Fluorouracil and its metabolites possess a number of different mechanisms of action. In vivo, fluoruracil is converted to the active metabolite 5-fluoroxyuridine monophosphate (F-UMP); replacing uracil, F-UMP incorporates into RNA and inhibits RNA processing, thereby inhibiting cell growth. Another active metabolite, 5-5-fluoro-2'-deoxyuridine-5'-O-monophosphate (F-dUMP), inhibits thymidylate synthase, resulting in the depletion of thymidine triphosphate (TTP), one of the four nucleotide triphosphates used in the in vivo synthesis of DNA. Other fluorouracil metabolites incorporate into both RNA and DNA; incorporation into RNA results in major effects on both RNA processing and functions. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C505" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C505" NCI Thesaurus)
Synonyms
AccuSite
Fluroblastin
5-FU injection
Ribofluor
5-fluoro-2,4(1H,3H)-pyrimidinedione
5-Fluracil
5FU injection
Fluracedyl
FU
fluouracil
Fluracil
Flurablastin
Efudex
2,4-dioxo-5-fluoropyrimidine
5Fluracil
Ro-2-9757
Fluril
5-fluorouracil injection
Fluorouracil
5fluorouracil
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Type http://www.w3.org/2002/07/owl#Class
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