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Physician Data Query
Id | http://purl.bioontology.org/ontology/PDQ/CDR0000043130
http://purl.bioontology.org/ontology/PDQ/CDR0000043130
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Preferred Name | fluorouracil injection |
Definitions |
An antimetabolite fluoropyrimidine analog of the nucleoside pyrimidine with antineoplastic activity. Fluorouracil and its metabolites possess a number of different mechanisms of action. In vivo, fluoruracil is converted to the active metabolite 5-fluoroxyuridine monophosphate (F-UMP); replacing uracil, F-UMP incorporates into RNA and inhibits RNA processing, thereby inhibiting cell growth. Another active metabolite, 5-5-fluoro-2'-deoxyuridine-5'-O-monophosphate (F-dUMP), inhibits thymidylate synthase, resulting in the depletion of thymidine triphosphate (TTP), one of the four nucleotide triphosphates used in the in vivo synthesis of DNA. Other fluorouracil metabolites incorporate into both RNA and DNA; incorporation into RNA results in major effects on both RNA processing and functions. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C505" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C505" NCI Thesaurus)
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Synonyms |
AccuSite
Fluroblastin
5-FU injection
Ribofluor
5-fluoro-2,4(1H,3H)-pyrimidinedione
5-Fluracil
5FU injection
Fluracedyl
FU
fluouracil
Fluracil
Flurablastin
Efudex
2,4-dioxo-5-fluoropyrimidine
5Fluracil
Ro-2-9757
Fluril
5-fluorouracil injection
Fluorouracil
5fluorouracil
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Type | http://www.w3.org/2002/07/owl#Class |
All Properties
definition | An antimetabolite fluoropyrimidine analog of the nucleoside pyrimidine with antineoplastic activity. Fluorouracil and its metabolites possess a number of different mechanisms of action. In vivo, fluoruracil is converted to the active metabolite 5-fluoroxyuridine monophosphate (F-UMP); replacing uracil, F-UMP incorporates into RNA and inhibits RNA processing, thereby inhibiting cell growth. Another active metabolite, 5-5-fluoro-2'-deoxyuridine-5'-O-monophosphate (F-dUMP), inhibits thymidylate synthase, resulting in the depletion of thymidine triphosphate (TTP), one of the four nucleotide triphosphates used in the in vivo synthesis of DNA. Other fluorouracil metabolites incorporate into both RNA and DNA; incorporation into RNA results in major effects on both RNA processing and functions. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C505" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C505" NCI Thesaurus) |
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altLabel |
AccuSite
Fluroblastin
5-FU injection
Ribofluor
5-fluoro-2,4(1H,3H)-pyrimidinedione
5-Fluracil
5FU injection
Fluracedyl
FU
fluouracil
Fluracil
Flurablastin
Efudex
2,4-dioxo-5-fluoropyrimidine
5Fluracil
Ro-2-9757
Fluril
5-fluorouracil injection
Fluorouracil
5fluorouracil
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prefLabel | fluorouracil injection
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CAS Registry | 51-21-8
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notation | CDR0000043130
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NSC Code | 19893
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ORIG STY | Drug/agent
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Component of |
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Legacy PDQ ID | 757
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Date last modified | 2018-04-19
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Semantic type UMLS property | |
NCI ID | C505
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type | |
LT | TRD
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tui |
T200
T114
T121
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cui |
C1517229
C1517230
C1517232
C4724252
C1522715
C0594005
C1522716
C0699372
C0016360
C1517231
C1522717
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