alfentanil hydrochloride

Rapifen

The hydrochloride salt of alfentanil, a synthetic short-acting opioid with analgesic and local anesthesia enhancing activity. Alfentanil hydrochloride primarily binds to mu-opioid receptor, a G-protein-coupled receptor, thereby mimicking the actions of morphine, the prototypical mu receptor agonist. This agent induces anti-nociception responses mediated through inhibiting the release of various neurotransmitters such as substance P, GABA, dopamine, acetylcholine and noradrenaline; in addition, the release of vasopressin, somatostatin, insulin and glucagon are also inhibited. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C220" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C220" NCI Thesaurus)

http://purl.bioontology.org/ontology/PDQ/CDR0000042783

Rapifen

Alfenta

70879-28-6

C0002025

C0700562

2011-08-11

The hydrochloride salt of alfentanil, a synthetic short-acting opioid with analgesic and local anesthesia enhancing activity. Alfentanil hydrochloride primarily binds to mu-opioid receptor, a G-protein-coupled receptor, thereby mimicking the actions of morphine, the prototypical mu receptor agonist. This agent induces anti-nociception responses mediated through inhibiting the release of various neurotransmitters such as substance P, GABA, dopamine, acetylcholine and noradrenaline; in addition, the release of vasopressin, somatostatin, insulin and glucagon are also inhibited. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C220" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C220" NCI Thesaurus)

6582

TRD

C220

CDR0000042783

Drug/agent

alfentanil hydrochloride

T109

T121