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Physician Data Query
| Preferred Name | alfentanil hydrochloride | |
| Synonyms |
Rapifen Alfenta |
|
| Definitions |
The hydrochloride salt of alfentanil, a synthetic short-acting opioid with analgesic and local anesthesia enhancing activity. Alfentanil hydrochloride primarily binds to mu-opioid receptor, a G-protein-coupled receptor, thereby mimicking the actions of morphine, the prototypical mu receptor agonist. This agent induces anti-nociception responses mediated through inhibiting the release of various neurotransmitters such as substance P, GABA, dopamine, acetylcholine and noradrenaline; in addition, the release of vasopressin, somatostatin, insulin and glucagon are also inhibited. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C220" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C220" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000042783 |
|
| altLabel |
Rapifen Alfenta
|
|
| CAS Registry |
70879-28-6
|
|
| cui |
C0002025 C0700562
|
|
| Date last modified |
2011-08-11
|
|
| definition |
The hydrochloride salt of alfentanil, a synthetic short-acting opioid with analgesic and local anesthesia enhancing activity. Alfentanil hydrochloride primarily binds to mu-opioid receptor, a G-protein-coupled receptor, thereby mimicking the actions of morphine, the prototypical mu receptor agonist. This agent induces anti-nociception responses mediated through inhibiting the release of various neurotransmitters such as substance P, GABA, dopamine, acetylcholine and noradrenaline; in addition, the release of vasopressin, somatostatin, insulin and glucagon are also inhibited. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C220" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C220" NCI Thesaurus)
|
|
| Legacy PDQ ID |
6582
|
|
| LT |
TRD
|
|
| NCI ID |
C220
|
|
| notation |
CDR0000042783
|
|
| ORIG STY |
Drug/agent
|
|
| prefLabel |
alfentanil hydrochloride
|
|
| tui |
T109 T121
|
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