gonadorelin

LHRH analogue

gonadoliberin

luliberin

Hoe- 471

LH-RH analogs

AY-24031

LH/FSH-RF analogue

GN-RH analogue

LH-RF analogue

luteinizing hormone-releasing hormone agonist

D-His-6-Pro-8-NEt-LHRH

gonadorelinum

GnRH analogue

luteinising hormone-releasing factor analogue

LH/FSH-RH analogue

follicle stimulating hormone-releasing factor

A synthetic analog of the endogenous hormone gonadotropin-releasing hormone (GnRH), with potential antineoplastic activity. Upon administration, GnRH analog mimics endogenous GnRH and strongly binds to and activates pituitary GnRH receptors, which stimulates the synthesis and secretion of the gonadotropic hormones, follicle stimulating hormone (FSH) and luteinizing hormone (LH). Continuous, prolonged activation by the GnRH analog results in pituitary GnRH receptor desensitization and receptor downregulation. This causes inhibition of pituitary gonadotropin secretion of LH and FSH. In males, the inhibition of LH secretion prevents the production and release of testosterone from Leydig cells in the testes and causes a significant decline in testosterone production that is near the levels seen after castration. This may inhibit androgen receptor-positive tumor progression. In females, this results in a decrease in estradiol production. GnRH, also called luteinizing hormone-releasing hormone (LH-RH), is normally synthesized in and secreted by the hypothalamus. Synthetic analogs of GnRH have a stronger receptor binding affinity than the endogenous form. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1910" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C1910" NCI Thesaurus)

http://purl.bioontology.org/ontology/PDQ/CDR0000042628

http://purl.bioontology.org/ontology/PDQ/CDR0000043017