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| Preferred Name | cidofovir | |
| Synonyms |
Vistide HPMPC 1(3-hydroxy-2-phosphonomethoxypropyl) Cytosine CDV |
|
| Definitions |
A synthetic, acyclic, monophosphate nucleotide analog of deoxycytidine with antiviral activity, and mostly used against cytomegalovirus (CMV). After incorporation into the host cell, cidofovir is phosphorylated by pyruvate kinases to its active metabolite cidofovir diphosphate. Cidofovir diphosphate, bearing structural similarity to nucleotides, competes with deoxycytosine-5-triphosphate (dCTP) for viral DNA polymerase and gets incorporated into the growing viral DNA strands. As a result, it prevents further DNA polymerization and disrupts DNA replication of viruses. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1600" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C1600" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000042545 |
|
| altLabel |
Vistide HPMPC 1(3-hydroxy-2-phosphonomethoxypropyl) Cytosine CDV
|
|
| CAS Registry |
113852-37-2
|
|
| cui |
C0286079 C0286078
|
|
| definition |
A synthetic, acyclic, monophosphate nucleotide analog of deoxycytidine with antiviral activity, and mostly used against cytomegalovirus (CMV). After incorporation into the host cell, cidofovir is phosphorylated by pyruvate kinases to its active metabolite cidofovir diphosphate. Cidofovir diphosphate, bearing structural similarity to nucleotides, competes with deoxycytosine-5-triphosphate (dCTP) for viral DNA polymerase and gets incorporated into the growing viral DNA strands. As a result, it prevents further DNA polymerization and disrupts DNA replication of viruses. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1600" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C1600" NCI Thesaurus)
|
|
| Legacy PDQ ID |
6196
|
|
| LT |
TRD
|
|
| NCI ID |
C1600
|
|
| notation |
CDR0000042545
|
|
| ORIG STY |
Drug/agent
|
|
| prefLabel |
cidofovir
|
|
| tui |
T114 T121
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