loading...| Preferred Name |
anastrozole |
|
| Synonyms |
Arimidex ICI D1033 ZD-1033 alpha,alpha,alpha', alpha'-tetramethyl-5-(1H-1,2,4-triazol-1-ylmethyl)-1,3-benzenediacetonitrile 2,2'-[5-(1H-1,2,4-triazol-1-ylmethyl)-1,3-phenylene]di(2-methylpropionitrile) ICI-D1033 ANAS |
|
| Definitions |
A nonsteroidal inhibitor of estrogen synthesis that resembles paclitaxel in chemical structure. As a third-generation aromatase inhibitor, anastrozole selectively binds to and reversibly inhibits aromatase, a cytochrome P-450 enzyme complex found in many tissues including those of the premenopausal ovary, liver, and breast; aromatase catalyzes the aromatization of androstenedione and testosterone into estrone and estradiol, the final step in estrogen biosynthesis. In estrogen-dependent breast cancers, anastrozole may inhibit tumor growth. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1607" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C1607" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000042540 |
|
| altLabel |
Arimidex ICI D1033 ZD-1033 alpha,alpha,alpha', alpha'-tetramethyl-5-(1H-1,2,4-triazol-1-ylmethyl)-1,3-benzenediacetonitrile 2,2'-[5-(1H-1,2,4-triazol-1-ylmethyl)-1,3-phenylene]di(2-methylpropionitrile) ICI-D1033 ANAS |
|
| CAS Registry |
120511-73-1 |
|
| Component of |
http://purl.bioontology.org/ontology/PDQ/CDR0000038369 http://purl.bioontology.org/ontology/PDQ/CDR0000445425 http://purl.bioontology.org/ontology/PDQ/CDR0000258295 http://purl.bioontology.org/ontology/PDQ/CDR0000321914 |
|
| cui |
C0290882 C0878174 C0290883 C0733865 |
|
| Date last modified |
2016-01-29 |
|
| definition |
A nonsteroidal inhibitor of estrogen synthesis that resembles paclitaxel in chemical structure. As a third-generation aromatase inhibitor, anastrozole selectively binds to and reversibly inhibits aromatase, a cytochrome P-450 enzyme complex found in many tissues including those of the premenopausal ovary, liver, and breast; aromatase catalyzes the aromatization of androstenedione and testosterone into estrone and estradiol, the final step in estrogen biosynthesis. In estrogen-dependent breast cancers, anastrozole may inhibit tumor growth. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1607" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C1607" NCI Thesaurus) |
|
| Legacy PDQ ID |
6187 |
|
| LT |
TRD |
|
| NCI ID |
C1607 |
|
| notation |
CDR0000042540 |
|
| NSC Code |
719344 |
|
| ORIG STY |
Drug/agent |
|
| prefLabel |
anastrozole |
|
| tui |
T109 T121 |