loading...| Preferred Name |
oprelvekin |
|
| Synonyms |
rhIL-11 |
|
| Definitions |
A recombinant therapeutic agent which is chemically identical to or similar to the endogenous cytokine interleukin 11 (IL-11). Secreted by bone marrow stromal cells and a number of mesenchymal cells, IL-11 binds to and activates its cell-surface receptor, promoting primary and secondary immune responses, modulating antigen-specific antibody reactions, and preventing apoptotic cell death. This agent also stimulates the T-cell-dependent development of IgG-secreting B-cells in spleen cell cultures and may be an important regulator of megakaryocytopoiesis. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1303" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C1303" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000042365 |
|
| altLabel |
rhIL-11 recombinant human interleukin-11 interleukin 11 Interleukin-11-Recombinant adipogenesis inhibitory factor therapeutic interleukin-11 Baijieyi IL-11 recombinant interleukin-11 Neumega |
|
| CAS Registry |
145941-26-0 |
|
| Component of |
http://purl.bioontology.org/ontology/PDQ/CDR0000043039 |
|
| cui |
C4732954 C0537670 C0537668 |
|
| Date last modified |
2018-03-09 |
|
| definition |
A recombinant therapeutic agent which is chemically identical to or similar to the endogenous cytokine interleukin 11 (IL-11). Secreted by bone marrow stromal cells and a number of mesenchymal cells, IL-11 binds to and activates its cell-surface receptor, promoting primary and secondary immune responses, modulating antigen-specific antibody reactions, and preventing apoptotic cell death. This agent also stimulates the T-cell-dependent development of IgG-secreting B-cells in spleen cell cultures and may be an important regulator of megakaryocytopoiesis. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1303" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C1303" NCI Thesaurus) |
|
| Legacy PDQ ID |
5619 |
|
| LT |
TRD |
|
| NCI ID |
C1303 |
|
| notation |
CDR0000042365 |
|
| ORIG STY |
Drug/agent |
|
| prefLabel |
oprelvekin |
|
| tui |
T116 T129 T121 |