loading...| Preferred Name | samarium Sm 153 lexidronam pentasodium | |
| Synonyms |
Samarium-153 EDTMP 153Sm-EDTMP Sm-153 EDTMP Sm 153 lexidronam pentasodium Quadramet samarium Sm 153 lexidronam |
|
| Definitions |
The pentasodium salt of samarium Sm 153 lexidronam, a therapeutic agent consisting of a medium energy beta- and gamma-emitting radioisotope, samarium Sm 153, and a teraphosphonate chelator, ethylenediaminetetramethylene phosphonic acid (EDTMP). The chelator moiety of samarium Sm 153 lexidronam associates with hydroxyapatite crystals concentrated in areas of bone turnover, thereby selectively delivering samarium Sm 153-mediated cytotoxic radiation to osteoblastic bone metastases. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1220" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C1220" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000042245 |
|
| altLabel |
Samarium-153 EDTMP 153Sm-EDTMP Sm-153 EDTMP Sm 153 lexidronam pentasodium Quadramet samarium Sm 153 lexidronam |
|
| Component of | ||
| cui |
C0701498 C0772051 C0993551 |
|
| Date last modified |
2013-01-31 |
|
| definition |
The pentasodium salt of samarium Sm 153 lexidronam, a therapeutic agent consisting of a medium energy beta- and gamma-emitting radioisotope, samarium Sm 153, and a teraphosphonate chelator, ethylenediaminetetramethylene phosphonic acid (EDTMP). The chelator moiety of samarium Sm 153 lexidronam associates with hydroxyapatite crystals concentrated in areas of bone turnover, thereby selectively delivering samarium Sm 153-mediated cytotoxic radiation to osteoblastic bone metastases. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1220" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C1220" NCI Thesaurus) |
|
| Legacy PDQ ID |
5495 |
|
| LT |
TRD |
|
| NCI ID |
C1220 |
|
| notation |
CDR0000042245 |
|
| ORIG STY |
Drug/agent |
|
| prefLabel |
samarium Sm 153 lexidronam pentasodium |
|
| tui |
T109 T130 T121 |