loading...| Preferred Name | alitretinoin | |
| Synonyms |
ALRT1057 9-CRA 9-cis Retinoic Acid Panretyn Panretin Panrexin 3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)2-trans-4-trans-6-cis-8-trans-nonatetraenoic Acid 3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)2-cis-4-trans-6-trans-8-trans-nonatetraenoic Acid 9-cis-retinoic acid LGD1057 9-cis-RA |
|
| Definitions |
An orally- and topically-active naturally-occurring retinoic acid with antineoplastic, chemopreventive, teratogenic, and embryotoxic activities. Alitretinoin binds to and activates nuclear retinoic acid receptors (RAR) and retinoid X receptors (RXR); these activated receptors act as transcription factors, regulating gene expression that results in the inhibition of cell proliferation, induction of cell differentiation, and apoptosis of both normal cells and tumor cells. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1574" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C1574" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000042147 |
|
| altLabel |
ALRT1057 9-CRA 9-cis Retinoic Acid Panretyn Panretin Panrexin 3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)2-trans-4-trans-6-cis-8-trans-nonatetraenoic Acid 3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)2-cis-4-trans-6-trans-8-trans-nonatetraenoic Acid 9-cis-retinoic acid LGD1057 9-cis-RA |
|
| CAS Registry |
5300-03-8 |
|
| Component of |
http://purl.bioontology.org/ontology/PDQ/CDR0000042368 |
|
| cui |
C1510846 C1510845 C0281666 C0722482 C0918022 C0022265 C0918021 |
|
| Date last modified |
2008-02-26 |
|
| definition |
An orally- and topically-active naturally-occurring retinoic acid with antineoplastic, chemopreventive, teratogenic, and embryotoxic activities. Alitretinoin binds to and activates nuclear retinoic acid receptors (RAR) and retinoid X receptors (RXR); these activated receptors act as transcription factors, regulating gene expression that results in the inhibition of cell proliferation, induction of cell differentiation, and apoptosis of both normal cells and tumor cells. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1574" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C1574" NCI Thesaurus) |
|
| IND Code |
48234 |
|
| Legacy PDQ ID |
5384 |
|
| LT |
TRD |
|
| NCI ID |
C1574 |
|
| notation |
CDR0000042147 |
|
| NSC Code |
659772 |
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| ORIG STY |
Drug/agent |
|
| prefLabel |
alitretinoin |
|
| tui |
T109 T127 T121 |