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Physician Data Query
| Preferred Name | tacrolimus | |
| Synonyms |
FK506 hexadecahydro-5,19-dihydroxy-3-[2-(4-hydroxy-3-methoxycyclohexyl)-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propenyl)-15,19-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone Hecoria FK-506 Advagraf fujimycin Prograf FK 506 |
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| Definitions |
A macrolide isolated from the fungus Streptomyces tsukubaensis. Tacrolimus binds to the FKBP-12 protein and forms a complex with calcium-dependent proteins, thereby inhibiting calcineurin phosphatase activity and resulting in decreased cytokine production. This agent exhibits potent immunosuppressive activity in vivo and prevents the activation of T-lymphocytes in response to antigenic or mitogenic stimulation. Tacrolimus possesses similar immunosuppressive properties to cyclosporine, but is more potent. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1311" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C1311" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000042009 |
|
| altLabel |
FK506 hexadecahydro-5,19-dihydroxy-3-[2-(4-hydroxy-3-methoxycyclohexyl)-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propenyl)-15,19-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone Hecoria FK-506 Advagraf fujimycin Prograf FK 506
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| CAS Registry |
109581-93-3 (monohydrate) 104987-11-3
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| Component of |
http://purl.bioontology.org/ontology/PDQ/CDR0000445235 http://purl.bioontology.org/ontology/PDQ/CDR0000038036 http://purl.bioontology.org/ontology/PDQ/CDR0000042485 http://purl.bioontology.org/ontology/PDQ/CDR0000271394 http://purl.bioontology.org/ontology/PDQ/CDR0000271395 http://purl.bioontology.org/ontology/PDQ/CDR0000380452 http://purl.bioontology.org/ontology/PDQ/CDR0000042591 http://purl.bioontology.org/ontology/PDQ/CDR0000380740 http://purl.bioontology.org/ontology/PDQ/CDR0000429484 http://purl.bioontology.org/ontology/PDQ/CDR0000415241 http://purl.bioontology.org/ontology/PDQ/CDR0000269773 http://purl.bioontology.org/ontology/PDQ/CDR0000368428 http://purl.bioontology.org/ontology/PDQ/CDR0000355817 http://purl.bioontology.org/ontology/PDQ/CDR0000038573 |
|
| cui |
C0678125 C3249359 C4721544 C4082808 C0729218 C0085149
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| Date last modified |
2015-12-03
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|
| definition |
A macrolide isolated from the fungus Streptomyces tsukubaensis. Tacrolimus binds to the FKBP-12 protein and forms a complex with calcium-dependent proteins, thereby inhibiting calcineurin phosphatase activity and resulting in decreased cytokine production. This agent exhibits potent immunosuppressive activity in vivo and prevents the activation of T-lymphocytes in response to antigenic or mitogenic stimulation. Tacrolimus possesses similar immunosuppressive properties to cyclosporine, but is more potent. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1311" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C1311" NCI Thesaurus)
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|
| Legacy PDQ ID |
5234
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|
| LT |
TRD
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| NCI ID |
C1311
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|
| notation |
CDR0000042009
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| NSC Code |
717865
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| ORIG STY |
Drug/agent
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|
| prefLabel |
tacrolimus
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|
| tui |
T109 T121
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