loading...| Preferred Name |
plicamycin |
|
| Synonyms |
Mithracin |
|
| Definitions |
An antibiotic isolated from the bacterium Streptomyces plicatus with antineoplastic activity. Plicamycin, also known as mithramycin, binds to the minor groove of DNA at GC-rich sites, resulting in inhibition of RNA synthesis; this agent also inhibits mRNA expression, resulting in a reduction in protein synthesis. In addition, plicamycin may inhibit bone resorption by down regulating transcription of c-src, an oncogene involved in bone metabolism and resorption. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C658" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C658" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000041738 |
|
| altLabel |
Mithracin Mithracine A-2371 aureolic acid MTH mithramycin PA-144 |
|
| CAS Registry |
18378-89-7 |
|
| cui |
C0702001 C0026234 C1514184 C0702002 C0702003 |
|
| Date last modified |
2008-10-16 |
|
| definition |
An antibiotic isolated from the bacterium Streptomyces plicatus with antineoplastic activity. Plicamycin, also known as mithramycin, binds to the minor groove of DNA at GC-rich sites, resulting in inhibition of RNA synthesis; this agent also inhibits mRNA expression, resulting in a reduction in protein synthesis. In addition, plicamycin may inhibit bone resorption by down regulating transcription of c-src, an oncogene involved in bone metabolism and resorption. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C658" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C658" NCI Thesaurus) |
|
| IND Code |
915 |
|
| Legacy PDQ ID |
491 |
|
| LT |
TRD |
|
| NCI ID |
C658 |
|
| notation |
CDR0000041738 |
|
| NSC Code |
24559 |
|
| ORIG STY |
Drug/agent |
|
| prefLabel |
plicamycin |
|
| tui |
T109 T195 T130 |