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Physician Data Query
| Preferred Name | TNP-470 | |
| Synonyms |
5-methoxy-4-(2-methyl-3-(3-methyl-2-butenyl)-1-oxaspiro(2,5)oct-6-yl(chloroacetyl) carbamate AGM-1470 (3R,4S,5S,6R)-5-methoxy-4- [(2R,3R)-2-methyl-3-(3-methyl-2-butenyl) -oxiranyl]-1-oxaspiro [2,5] oct-6-yl(chloroacetyl) carbamate O-(chloroacetylcarbamoyl)fumagillol |
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| Definitions |
A synthetic analog of fumagillin, an antibiotic isolated from the fungus Aspergillus fumigatus fresenius with antineoplastic activity. TNP-470 binds to and irreversibly inactivates methionine animopeptidase-2 (MetAP2), resulting in endothelial cell cycle arrest late in the G1 phase and inhibition of tumor angiogenesis. This agent may also induce the p53 pathway, thereby stimulating the production of cyclin-dependent kinase inhibitor p21 and inhibiting angiogenesis. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1298" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C1298" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000041725 |
|
| altLabel |
5-methoxy-4-(2-methyl-3-(3-methyl-2-butenyl)-1-oxaspiro(2,5)oct-6-yl(chloroacetyl) carbamate AGM-1470 (3R,4S,5S,6R)-5-methoxy-4- [(2R,3R)-2-methyl-3-(3-methyl-2-butenyl) -oxiranyl]-1-oxaspiro [2,5] oct-6-yl(chloroacetyl) carbamate O-(chloroacetylcarbamoyl)fumagillol
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| CAS Registry |
129298-91-5
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|
| cui |
C0950779 C0950778 C0081489
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| Date last modified |
2010-06-09
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|
| definition |
A synthetic analog of fumagillin, an antibiotic isolated from the fungus Aspergillus fumigatus fresenius with antineoplastic activity. TNP-470 binds to and irreversibly inactivates methionine animopeptidase-2 (MetAP2), resulting in endothelial cell cycle arrest late in the G1 phase and inhibition of tumor angiogenesis. This agent may also induce the p53 pathway, thereby stimulating the production of cyclin-dependent kinase inhibitor p21 and inhibiting angiogenesis. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1298" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C1298" NCI Thesaurus)
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| IND Code |
40065
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| Legacy PDQ ID |
4895
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|
| NCI ID |
C1298
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|
| notation |
CDR0000041725
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| NSC Code |
642492
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| ORIG STY |
Drug/agent
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|
| prefLabel |
TNP-470
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| tui |
T109 T195 T121
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