Link to this page
Physician Data Query
Last uploaded:
August 27, 2019
Jump to:
| Id | http://purl.bioontology.org/ontology/PDQ/CDR0000041719
http://purl.bioontology.org/ontology/PDQ/CDR0000041719
|
|---|---|
| Preferred Name | methotrexate |
| Definitions |
An antimetabolite and antifolate agent with antineoplastic and immunosuppressant activities. Methotrexate binds to and inhibits the enzyme dihydrofolate reductase, resulting in inhibition of purine nucleotide and thymidylate synthesis and, subsequently, inhibition of DNA and RNA syntheses. Methotrexate also exhibits potent immunosuppressant activity although the mechanism(s) of actions is unclear. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C642" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C642" NCI Thesaurus)
|
| Synonyms |
Emtexate
Ledertrexate
Rheumatrex
Metex
Tremetex
Lantarel
Metotrexato
Brimexate
Novatrex
amethopterin
4-amino-4-deoxy-10-methylpteroyl-L-glutamic acid
Trexall
MTX
Methoblastin
Emthexate
Lumexon
methotrexate methylaminopterin
Trixilem
4-amino-10-methylfolic acid
methylaminopterin
Maxtrex
Metrotex
CL-14377
Emthexat
Farmitrexat
Fauldexato
WR-19039
Texate
Trexeron
Methotrexatum
N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-glutamic acid
alpha-methopterin
Medsatrexate
See more
See less
|
| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | An antimetabolite and antifolate agent with antineoplastic and immunosuppressant activities. Methotrexate binds to and inhibits the enzyme dihydrofolate reductase, resulting in inhibition of purine nucleotide and thymidylate synthesis and, subsequently, inhibition of DNA and RNA syntheses. Methotrexate also exhibits potent immunosuppressant activity although the mechanism(s) of actions is unclear. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C642" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C642" NCI Thesaurus) |
|---|---|
| altLabel |
Emtexate
Ledertrexate
Rheumatrex
Metex
Tremetex
Lantarel
Metotrexato
Brimexate
Novatrex
amethopterin
4-amino-4-deoxy-10-methylpteroyl-L-glutamic acid
Trexall
MTX
Methoblastin
Emthexate
Lumexon
methotrexate methylaminopterin
Trixilem
4-amino-10-methylfolic acid
methylaminopterin
Maxtrex
Metrotex
CL-14377
Emthexat
Farmitrexat
Fauldexato
WR-19039
Texate
Trexeron
Methotrexatum
N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-glutamic acid
alpha-methopterin
Medsatrexate
See more
See less
|
| prefLabel | methotrexate
|
| CAS Registry | 59-05-2
|
| notation | CDR0000041719
|
| NSC Code | 740
|
| ORIG STY | Drug/agent
|
| Component of |
See more
See less
|
| Legacy PDQ ID | 489
|
| Date last modified | 2018-03-01
|
| Semantic type UMLS property | |
| NCI ID | C642
|
| type | |
| IND Code |
7723
4291
|
| LT | TRD
|
| tui |
T109
T116
T121
|
| cui |
C1513197
C1513200
C1513212
C1513198
C1513201
C1513205
C1161371
C1513208
C0025677
C1527140
C1513206
C1513211
C1513213
C1513202
C1527141
C1513203
C0591758
C0939510
C1513204
C1513214
C1513207
C1513210
C1513209
See more
See less
|
Add comment
| Delete | Subject | Author | Type | Created |
|---|---|---|---|---|
| No notes to display |