Link to this page
Physician Data Query
| Id | http://purl.bioontology.org/ontology/PDQ/CDR0000041670
http://purl.bioontology.org/ontology/PDQ/CDR0000041670
|
|---|---|
| Preferred Name | lometrexol |
| Definitions |
A folate analog antimetabolite with antineoplastic activity. As the 6R diastereomer of 5,10-dideazatetrahydrofolate, lometrexol inhibits glycinamide ribonucleotide formyltransferase (GARFT), the enzyme that catalyzes the first step in the de novo purine biosynthetic pathway, thereby inhibiting DNA synthesis, arresting cells in the S phase of the cell cycle, and inhibiting tumor cell proliferation. The agent has been shown to be active against tumors that are resistant to the folate antagonist methotrexate. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C979" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C979" NCI Thesaurus)
|
| Synonyms |
Pyrido[2,3-d]pyrimidine, L-glutamic acid derivative (9CI)
L-Glutamic acid, N-(4-(2-(2-amino-1,4,5,6,7,8-hexahydro-4-oxopyrido(2,3-d)pyrimidin-6-yl)ethyl)benzoyl)-, (R)-
LMTX
L-Glutamic acid, N-(4-(2-((6R)-2-amino-1,4,5,6,7,8-hexahydro-4-oxopyrido(2,3-d)pyrimidin-6-yl)ethyl)benzoyl)-
(6R)-DDATHF
6R-5,10-Dideazatetrahydrofolate
|
| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A folate analog antimetabolite with antineoplastic activity. As the 6R diastereomer of 5,10-dideazatetrahydrofolate, lometrexol inhibits glycinamide ribonucleotide formyltransferase (GARFT), the enzyme that catalyzes the first step in the de novo purine biosynthetic pathway, thereby inhibiting DNA synthesis, arresting cells in the S phase of the cell cycle, and inhibiting tumor cell proliferation. The agent has been shown to be active against tumors that are resistant to the folate antagonist methotrexate. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C979" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C979" NCI Thesaurus) |
|---|---|
| altLabel | Pyrido[2,3-d]pyrimidine, L-glutamic acid derivative (9CI)
L-Glutamic acid, N-(4-(2-(2-amino-1,4,5,6,7,8-hexahydro-4-oxopyrido(2,3-d)pyrimidin-6-yl)ethyl)benzoyl)-, (R)-
LMTX
L-Glutamic acid, N-(4-(2-((6R)-2-amino-1,4,5,6,7,8-hexahydro-4-oxopyrido(2,3-d)pyrimidin-6-yl)ethyl)benzoyl)-
(6R)-DDATHF
6R-5,10-Dideazatetrahydrofolate
See more
See less
|
| prefLabel | lometrexol
|
| CAS Registry | 106400-81-1
|
| notation | CDR0000041670
|
| NSC Code | 660025
|
| ORIG STY | Drug/agent
|
| Component of | |
| Legacy PDQ ID | 4833
|
| Semantic type UMLS property | |
| NCI ID | C979
|
| type | |
| IND Code | 46981
|
| tui |
T109
T121
|
| cui | C0048852
|
| Delete | Subject | Author | Type | Created |
|---|---|---|---|---|
| No notes to display |
- Loading...