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Physician Data Query
| Id | http://purl.bioontology.org/ontology/PDQ/CDR0000041657
http://purl.bioontology.org/ontology/PDQ/CDR0000041657
|
|---|---|
| Preferred Name | docetaxel |
| Definitions |
A semi-synthetic, second-generation taxane derived from a compound found in the European yew tree Taxus baccata. Docetaxel displays potent and broad antineoplastic properties; it binds to and stabilizes tubulin, thereby inhibiting microtubule disassembly which results in cell- cycle arrest at the G2/M phase and cell death. This agent also inhibits pro-angiogenic factors such as vascular endothelial growth factor (VEGF) and displays immunomodulatory and pro-inflammatory properties by inducing various mediators of the inflammatory response. Docetaxel has been studied for use as a radiation-sensitizing agent. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1526" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C1526" NCI Thesaurus)
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| Synonyms |
Docecad
RP 56976
RP56976
TXT
[2aR-[2a alphaa,4beta,4a beta,6beta,9alpha,(alphaR*,betaS*),-11alpha,12alpha,12a alpha,12b alpha]]-beta-[[(1,1-dimethylethoxy)carbonyl]-amino]-alpha-hydroxybenzemepropanoic acid 12b-(Acetyloxy)-12(benzyloxy)-2a,3,4,4a,5,6,8,10,11,12,12a,12b-dodecahydeo-4,-6,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester
N-debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol
Taxotere
|
| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A semi-synthetic, second-generation taxane derived from a compound found in the European yew tree Taxus baccata. Docetaxel displays potent and broad antineoplastic properties; it binds to and stabilizes tubulin, thereby inhibiting microtubule disassembly which results in cell- cycle arrest at the G2/M phase and cell death. This agent also inhibits pro-angiogenic factors such as vascular endothelial growth factor (VEGF) and displays immunomodulatory and pro-inflammatory properties by inducing various mediators of the inflammatory response. Docetaxel has been studied for use as a radiation-sensitizing agent. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1526" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C1526" NCI Thesaurus) |
|---|---|
| altLabel |
Docecad
RP 56976
RP56976
TXT
[2aR-[2a alphaa,4beta,4a beta,6beta,9alpha,(alphaR*,betaS*),-11alpha,12alpha,12a alpha,12b alpha]]-beta-[[(1,1-dimethylethoxy)carbonyl]-amino]-alpha-hydroxybenzemepropanoic acid 12b-(Acetyloxy)-12(benzyloxy)-2a,3,4,4a,5,6,8,10,11,12,12a,12b-dodecahydeo-4,-6,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester
N-debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol
Taxotere
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|
| prefLabel |
docetaxel
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| CAS Registry |
114977-28-5
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| notation |
CDR0000041657
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| NSC Code |
628503
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| ORIG STY |
Drug/agent
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| Component of |
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|
| Legacy PDQ ID |
4819
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| Date last modified |
2018-03-01
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| Semantic type UMLS property | |
| NCI ID |
C1526
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| type | |
| IND Code |
40466
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| LT |
TRD
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| tui |
T109
T121
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| cui |
C0733872
C0246415
C4087017
C0771375
C0699967
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| Delete | Subject | Author | Type | Created |
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| No notes to display |