loading...| Preferred Name |
theophylline |
|
| Synonyms |
Somophyllin-T 1,3-dimethylxanthine monohydrate 3,7-dihydro-1,3-dimethyl-1H-purine-2,6-dione monohydrate Theochron Slo-bid theophylline monohydrate Uniphyl Theobid Duracap T-Phyl Theo-24 LaBID Elixophyllin 3,7-dihydro-1,3-dimethyl-1H-purine-2,6-dione Respbid Constant-T Slo-Phyllin Somophyllin-CRT |
|
| Definitions |
A natural alkaloid derivative of xanthine isolated from the plants Camellia sinensis and Coffea arabica. Theophylline appears to inhibit phosphodiesterase and prostaglandin production, regulate calcium flux and intracellular calcium distribution, and antagonize adenosine. Physiologically, this agent relaxes bronchial smooth muscle, produces vasodilation (except in cerebral vessels), stimulates the CNS, stimulates cardiac muscle, induces diuresis, and increases gastric acid secretion; it may also suppress inflammation and improve contractility of the diaphragm. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C872" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C872" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000041340 |
|
| altLabel |
Somophyllin-T 1,3-dimethylxanthine monohydrate 3,7-dihydro-1,3-dimethyl-1H-purine-2,6-dione monohydrate Theochron Slo-bid theophylline monohydrate Uniphyl Theobid Duracap T-Phyl Theo-24 LaBID Elixophyllin 3,7-dihydro-1,3-dimethyl-1H-purine-2,6-dione Respbid Constant-T Slo-Phyllin Somophyllin-CRT |
|
| CAS Registry |
58-55-9 (anhydrous) 5967-84-0 |
|
| cui |
C0700831 C0700842 C0700839 C0700825 C0700838 C0039771 C0700827 C0700840 C0700814 C0700841 C0700044 C0700845 C0700843 C0304443 C0700844 |
|
| definition |
A natural alkaloid derivative of xanthine isolated from the plants Camellia sinensis and Coffea arabica. Theophylline appears to inhibit phosphodiesterase and prostaglandin production, regulate calcium flux and intracellular calcium distribution, and antagonize adenosine. Physiologically, this agent relaxes bronchial smooth muscle, produces vasodilation (except in cerebral vessels), stimulates the CNS, stimulates cardiac muscle, induces diuresis, and increases gastric acid secretion; it may also suppress inflammation and improve contractility of the diaphragm. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C872" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C872" NCI Thesaurus) |
|
| Legacy PDQ ID |
4412 |
|
| LT |
TRD |
|
| NCI ID |
C872 |
|
| notation |
CDR0000041340 |
|
| NSC Code |
2066 |
|
| ORIG STY |
Drug/agent |
|
| prefLabel |
theophylline |
|
| tui |
T109 T121 |