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Physician Data Query
| Preferred Name | penicillin V potassium | |
| Synonyms |
Pen-Vee |
|
| Definitions |
The potassium salt of penicillin V, a member of the penicillin antibiotic family with broad-spectrum bactericidal activity. Penicillin V binds to and inactivates penicillin-binding proteins (PBPs), enzymes located on the inner membrane of the bacterial cell wall, resulting in the weakening of the bacterial cell wall and cell lysis. PBPs participate in the terminal stages of assembling the bacterial cell wall, and in reshaping the cell wall during cell division. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C730" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C730" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000040795 |
|
| altLabel |
Pen-Vee
|
|
| Component of | ||
| cui |
C0700553 C0700986
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| Date last modified |
2006-11-21
|
|
| definition |
The potassium salt of penicillin V, a member of the penicillin antibiotic family with broad-spectrum bactericidal activity. Penicillin V binds to and inactivates penicillin-binding proteins (PBPs), enzymes located on the inner membrane of the bacterial cell wall, resulting in the weakening of the bacterial cell wall and cell lysis. PBPs participate in the terminal stages of assembling the bacterial cell wall, and in reshaping the cell wall during cell division. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C730" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C730" NCI Thesaurus)
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|
| Legacy PDQ ID |
3759
|
|
| LT |
TRD
|
|
| NCI ID |
C730
|
|
| notation |
CDR0000040795
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|
| ORIG STY |
Drug/agent
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|
| prefLabel |
penicillin V potassium
|
|
| tui |
T109 T195
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