loading...| Preferred Name |
recombinant interferon gamma |
|
| Synonyms |
gamma-interferon |
|
| Definitions |
A recombinant therapeutic agent which is chemically identical to or similar to the endogenous lymphokine interferon gamma (IFN-gamma) with antineoplastic, immunoregulatory, and antiviral activities. Therapeutic IFN-gamma binds to and activates the cell-surface IFN-gamma receptor, stimulating antibody-dependent cytotoxicity and enhances natural killer cell attachment to tumor cells. This agent also activates caspases, thereby inducing apoptosis in malignant cells. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C583" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C583" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000040469 |
|
| altLabel |
gamma-interferon gamma interferon IFN-G |
|
| CAS Registry |
82115-62-6 |
|
| Component of |
http://purl.bioontology.org/ontology/PDQ/CDR0000041249 http://purl.bioontology.org/ontology/PDQ/CDR0000041304 http://purl.bioontology.org/ontology/PDQ/CDR0000040883 http://purl.bioontology.org/ontology/PDQ/CDR0000043679 http://purl.bioontology.org/ontology/PDQ/CDR0000038061 http://purl.bioontology.org/ontology/PDQ/CDR0000042457 http://purl.bioontology.org/ontology/PDQ/CDR0000041667 http://purl.bioontology.org/ontology/PDQ/CDR0000042861 http://purl.bioontology.org/ontology/PDQ/CDR0000042058 http://purl.bioontology.org/ontology/PDQ/CDR0000038843 http://purl.bioontology.org/ontology/PDQ/CDR0000041706 http://purl.bioontology.org/ontology/PDQ/CDR0000304319 http://purl.bioontology.org/ontology/PDQ/CDR0000042390 http://purl.bioontology.org/ontology/PDQ/CDR0000039670 http://purl.bioontology.org/ontology/PDQ/CDR0000042557 http://purl.bioontology.org/ontology/PDQ/CDR0000041998 http://purl.bioontology.org/ontology/PDQ/CDR0000041116 http://purl.bioontology.org/ontology/PDQ/CDR0000356027 http://purl.bioontology.org/ontology/PDQ/CDR0000355635 |
|
| cui |
C0021745 C3539881 |
|
| Date last modified |
2016-11-09 |
|
| definition |
A recombinant therapeutic agent which is chemically identical to or similar to the endogenous lymphokine interferon gamma (IFN-gamma) with antineoplastic, immunoregulatory, and antiviral activities. Therapeutic IFN-gamma binds to and activates the cell-surface IFN-gamma receptor, stimulating antibody-dependent cytotoxicity and enhances natural killer cell attachment to tumor cells. This agent also activates caspases, thereby inducing apoptosis in malignant cells. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C583" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C583" NCI Thesaurus) |
|
| IND Code |
1951 1706 4521 2591 2192 |
|
| Legacy PDQ ID |
3349 |
|
| NCI ID |
C583 |
|
| notation |
CDR0000040469 |
|
| NSC Code |
600662 373360 635256 |
|
| ORIG STY |
Drug/agent |
|
| prefLabel |
recombinant interferon gamma |
|
| tui |
T116 T129 T121 |