loading...| Preferred Name | recombinant interferon beta | |
| Synonyms |
human interferon beta beta interferon interferon beta Naferon Feron interferon-beta Betantrone interferon, beta interferon-B |
|
| Definitions |
A recombinant protein which is chemically identical to or similar to endogenous interferon beta with antiviral and anti-tumor activities. Endogenous interferons beta are cytokines produced by nucleated cells (predominantly natural killer cells) upon exposure to live or inactivated virus, double-stranded RNA or bacterial products. These agents bind to specific cell-surface receptors, resulting in the transcription and translation of genes with an interferon-specific response element. The proteins so produced mediate many complex effects, including antiviral (the most important being inhibition of viral protein synthesis), antiproliferative and immune modulating effects. The recombinant therapeutic forms of interferon beta are interferon beta 1-a and interferon beta 1-b. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C495" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C495" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000040468 |
|
| altLabel |
human interferon beta beta interferon interferon beta Naferon Feron interferon-beta Betantrone interferon, beta interferon-B |
|
| CAS Registry |
77238-31-4 |
|
| Component of |
http://purl.bioontology.org/ontology/PDQ/CDR0000038842 http://purl.bioontology.org/ontology/PDQ/CDR0000039653 http://purl.bioontology.org/ontology/PDQ/CDR0000038843 |
|
| cui |
C1515382 C0751599 C1515380 C1515381 |
|
| Date last modified |
2017-11-08 |
|
| definition |
A recombinant protein which is chemically identical to or similar to endogenous interferon beta with antiviral and anti-tumor activities. Endogenous interferons beta are cytokines produced by nucleated cells (predominantly natural killer cells) upon exposure to live or inactivated virus, double-stranded RNA or bacterial products. These agents bind to specific cell-surface receptors, resulting in the transcription and translation of genes with an interferon-specific response element. The proteins so produced mediate many complex effects, including antiviral (the most important being inhibition of viral protein synthesis), antiproliferative and immune modulating effects. The recombinant therapeutic forms of interferon beta are interferon beta 1-a and interferon beta 1-b. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C495" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C495" NCI Thesaurus) |
|
| Legacy PDQ ID |
3348 |
|
| LT |
TRD |
|
| NCI ID |
C495 |
|
| notation |
CDR0000040468 |
|
| NSC Code |
658933 373361 |
|
| ORIG STY |
Drug/agent |
|
| prefLabel |
recombinant interferon beta |
|
| tui |
T116 T129 T121 |
| Delete | Mapping To | Ontology | Source |
|---|---|---|---|
| http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C495 | NCIT | LOOM | |
| http://purl.obolibrary.org/obo/NCIT_C495 | BERO | LOOM |