vinorelbine ditartrate

Eunades

Navelbine

KW-2307

NVB

Biovelbin

navelbine ditartrate

The ditartrate salt of a semisynthetic vinca alkaloid derived from the leaves of the periwinkle plant (Vinca rosea) with antineoplastic activity. Vinorelbine binds to tubulin, thereby inhibiting tubulin polymerization into microtubules and spindle formation and resulting in apoptosis of susceptible cancer cells. Inhibition of mitotic microtubules correlates with antitumor activity, whereas inhibition of axonal microtubules seems to correlate with vinorelbine's neurotoxicity. Compared to related vinca alkaloids, vinorelbine is more selective against mitotic than axonal microtubules in vitro, which may account for its decreased neurotoxicity. This agent is also a radiation-sensitizing agent. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1395" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C1395" NCI Thesaurus)

http://purl.bioontology.org/ontology/PDQ/CDR0000040449

http://purl.bioontology.org/ontology/PDQ/CDR0000037879

http://purl.bioontology.org/ontology/PDQ/CDR0000041648

http://purl.bioontology.org/ontology/PDQ/CDR0000041700

http://purl.bioontology.org/ontology/PDQ/CDR0000391853

http://purl.bioontology.org/ontology/PDQ/CDR0000037956

http://purl.bioontology.org/ontology/PDQ/CDR0000042349

http://purl.bioontology.org/ontology/PDQ/CDR0000037963

http://purl.bioontology.org/ontology/PDQ/CDR0000378335

http://purl.bioontology.org/ontology/PDQ/CDR0000042335

http://purl.bioontology.org/ontology/PDQ/CDR0000042354

http://purl.bioontology.org/ontology/PDQ/CDR0000349698

http://purl.bioontology.org/ontology/PDQ/CDR0000038464

http://purl.bioontology.org/ontology/PDQ/CDR0000042566

http://purl.bioontology.org/ontology/PDQ/CDR0000043124

http://purl.bioontology.org/ontology/PDQ/CDR0000043483

http://purl.bioontology.org/ontology/PDQ/CDR0000038695

http://purl.bioontology.org/ontology/PDQ/CDR0000042961

http://purl.bioontology.org/ontology/PDQ/CDR0000041647

http://purl.bioontology.org/ontology/PDQ/CDR0000042219

http://purl.bioontology.org/ontology/PDQ/CDR0000043645

http://purl.bioontology.org/ontology/PDQ/CDR0000361548

http://purl.bioontology.org/ontology/PDQ/CDR0000043532

http://purl.bioontology.org/ontology/PDQ/CDR0000037962

http://purl.bioontology.org/ontology/PDQ/CDR0000038538

http://purl.bioontology.org/ontology/PDQ/CDR0000041705

http://purl.bioontology.org/ontology/PDQ/CDR0000038322

http://purl.bioontology.org/ontology/PDQ/CDR0000042336

http://purl.bioontology.org/ontology/PDQ/CDR0000041946

http://purl.bioontology.org/ontology/PDQ/CDR0000037967

http://purl.bioontology.org/ontology/PDQ/CDR0000038261

http://purl.bioontology.org/ontology/PDQ/CDR0000043637

http://purl.bioontology.org/ontology/PDQ/CDR0000042241

http://purl.bioontology.org/ontology/PDQ/CDR0000037901

http://purl.bioontology.org/ontology/PDQ/CDR0000038023

http://purl.bioontology.org/ontology/PDQ/CDR0000043660