loading...| Preferred Name |
pentosan polysulfate sodium |
|
| Synonyms |
HOE/BAY 946 |
|
| Definitions |
The sodium salt of a semisynthetic heparin-like glucosaminoglycan. Although its mechanism of action is unknown, pentosan polysulfate may act as a buffer to control cell permeability by preventing irritating solutes from reaching cells coated with it. Administered orally, excreted pentosan polysulfate adheres to the urinary bladder wall, preventing irritants from entering bladder cells and the development or progression of interstitial cystitis (IC), a complication of some chemotherapies. This agent also exhibits anticoagulant and fibrinolytic properties. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C946" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C946" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000040350 |
|
| altLabel |
HOE/BAY 946 Hemoclar PPS SP-54 Tavan SP-54 Fibrocid Elmiron Fibrezym |
|
| CAS Registry |
116001-96-8 |
|
| cui |
C0684241 C0524684 C0600294 C0600293 C0740027 C0600295 C0740028 C1518956 |
|
| Date last modified |
2008-10-13 |
|
| definition |
The sodium salt of a semisynthetic heparin-like glucosaminoglycan. Although its mechanism of action is unknown, pentosan polysulfate may act as a buffer to control cell permeability by preventing irritating solutes from reaching cells coated with it. Administered orally, excreted pentosan polysulfate adheres to the urinary bladder wall, preventing irritants from entering bladder cells and the development or progression of interstitial cystitis (IC), a complication of some chemotherapies. This agent also exhibits anticoagulant and fibrinolytic properties. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C946" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C946" NCI Thesaurus) |
|
| Legacy PDQ ID |
3202 |
|
| LT |
TRD |
|
| NCI ID |
C946 |
|
| notation |
CDR0000040350 |
|
| ORIG STY |
Drug/agent |
|
| prefLabel |
pentosan polysulfate sodium |
|
| tui |
T109 T121 |