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Physician Data Query
Last uploaded:
August 27, 2019
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| Id | http://purl.bioontology.org/ontology/PDQ/CDR0000040349
http://purl.bioontology.org/ontology/PDQ/CDR0000040349
|
|---|---|
| Preferred Name | zalcitabine |
| Definitions |
A synthetic dideoxynucleoside. After intracellular phosphorylation to its active metabolite, zalcitabine preferentially inhibits the gamma form of DNA polymerase present in tumor cell mitochondria, resulting in the inhibition of tumor cell mitochondrial DNA replication and tumor cell death. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C430" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C430" NCI Thesaurus)
|
| Synonyms |
Hivid
2',3'-dideoxycytidine
ddC
dideoxycytidine
|
| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A synthetic dideoxynucleoside. After intracellular phosphorylation to its active metabolite, zalcitabine preferentially inhibits the gamma form of DNA polymerase present in tumor cell mitochondria, resulting in the inhibition of tumor cell mitochondrial DNA replication and tumor cell death. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C430" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C430" NCI Thesaurus) |
|---|---|
| altLabel |
Hivid
2',3'-dideoxycytidine
ddC
dideoxycytidine
|
| prefLabel |
zalcitabine
|
| CAS Registry |
7481-89-2
|
| notation |
CDR0000040349
|
| NSC Code |
606170
|
| ORIG STY |
Drug/agent
|
| Component of | |
| Legacy PDQ ID |
3201
|
| Semantic type UMLS property | |
| NCI ID |
C430
|
| type | |
| IND Code |
33134
28975
30858
|
| LT |
TRD
|
| tui |
T114
T121
|
| cui |
C0012132
C0678123
|
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