loading...| Preferred Name |
piritrexim |
|
| Synonyms |
Piritrexim Isethionate |
|
| Definitions |
A synthetic antifolate agent with antiparasitic, antipsoriatic and antitumor properties. Piritrexim inhibits the enzyme dihydrofolate reductase enzyme, thereby disrupting folate metabolism and DNA synthesis and cell division. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1031" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C1031" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000040070 |
|
| altLabel |
Piritrexim Isethionate 6-((2,5-dimethoxyphenyl)methyl)-5-methylpyrido(2,3-d)pyrimidine-2,4-diamine 6-[(2,5-dimethoxyphenyl)methyl]-5-methylpyrido[2,3-d]pyrimidine-2,4-diamine BW-301U 2,4-diamino-6-(2,5-dimethoxybenzyl)-5-methylpyrido[2,3-d]pyrimidine |
|
| CAS Registry |
72732-56-0 |
|
| Component of | ||
| cui |
C1522061 C0701495 C0054332 |
|
| definition |
A synthetic antifolate agent with antiparasitic, antipsoriatic and antitumor properties. Piritrexim inhibits the enzyme dihydrofolate reductase enzyme, thereby disrupting folate metabolism and DNA synthesis and cell division. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1031" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C1031" NCI Thesaurus) |
|
| Legacy PDQ ID |
2812 |
|
| NCI ID |
C1031 |
|
| notation |
CDR0000040070 |
|
| NSC Code |
351521 |
|
| ORIG STY |
Drug/agent |
|
| prefLabel |
piritrexim |
|
| tui |
T109 T121 |