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Physician Data Query
Id | http://purl.bioontology.org/ontology/PDQ/CDR0000039762
http://purl.bioontology.org/ontology/PDQ/CDR0000039762
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Preferred Name | paclitaxel |
Definitions |
A compound extracted from the Pacific yew tree Taxus brevifolia with antineoplastic activity. Paclitaxel binds to tubulin and inhibits the disassembly of microtubules, thereby resulting in the inhibition of cell division. This agent also induces apoptosis by binding to and blocking the function of the apoptosis inhibitor protein Bcl-2 (B-cell Leukemia 2). Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1411" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C1411" NCI Thesaurus)
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Synonyms |
Anzatax
Praxel
Bristaxol
5beta,20-epoxy-1,2alpha,4,7beta,10beta,13alpha-hexahydroxytax-11-en-9-one, 4,10-diacetate 2-benzoate 13-ester with (2R,3S)-N-benzoyl-3-phenylisoserine
[2aR-[2a alpha,4beta,4a beta,6beta,9alpha(alphaR*,betaS*),-11alpha,12alpha,12a alpha,12b alpha]]-beta-(benzoylamino)-alpha-hydroxybenzene-propanoic acid 6,12b-bis(acetyloxy)-12-(benzoyloxy)-1a,33,4,-41,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-41,8,-12,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester
Asotax
Taxol Konzentrat
Taxol
TAX
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Type | http://www.w3.org/2002/07/owl#Class |
All Properties
definition | A compound extracted from the Pacific yew tree Taxus brevifolia with antineoplastic activity. Paclitaxel binds to tubulin and inhibits the disassembly of microtubules, thereby resulting in the inhibition of cell division. This agent also induces apoptosis by binding to and blocking the function of the apoptosis inhibitor protein Bcl-2 (B-cell Leukemia 2). Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1411" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C1411" NCI Thesaurus) |
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altLabel | Anzatax
Praxel
Bristaxol
5beta,20-epoxy-1,2alpha,4,7beta,10beta,13alpha-hexahydroxytax-11-en-9-one, 4,10-diacetate 2-benzoate 13-ester with (2R,3S)-N-benzoyl-3-phenylisoserine
[2aR-[2a alpha,4beta,4a beta,6beta,9alpha(alphaR*,betaS*),-11alpha,12alpha,12a alpha,12b alpha]]-beta-(benzoylamino)-alpha-hydroxybenzene-propanoic acid 6,12b-bis(acetyloxy)-12-(benzoyloxy)-1a,33,4,-41,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-41,8,-12,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester
Asotax
Taxol Konzentrat
Taxol
TAX
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prefLabel | paclitaxel
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CAS Registry | 33069-62-4
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notation | CDR0000039762
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NSC Code |
125973
673089
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ORIG STY | Drug/agent
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Component of |
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Legacy PDQ ID | 2424
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Date last modified | 2016-07-08
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Semantic type UMLS property | |
NCI ID | C1411
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type | |
IND Code | 22850
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LT | TRD
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tui |
T109
T121
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cui |
C1518837
C0678133
C1518838
C0144576
C1518840
C1518839
C1518836
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