loading...| Preferred Name | cholecalciferol | |
| Synonyms |
Calciol 9,10-secocholesta-5,7,10(19)-trien-3-beta-ol (3beta,5Z,7E)-9,10-secocholesta-5,7,10(19)-trien-3-ol delsterol 9,10-secocholesta-5,7,10(19)-trien-3-ol Vitamin D3 |
|
| Definitions |
A steroid hormone produced in the skin when exposed to ultraviolet light or obtained from dietary sources. The active form of cholecalciferol, 1,25-dihydroxycholecalciferol (calcitriol) plays an important role in maintaining blood calcium and phosphorus levels and mineralization of bone. The activated form of cholecalciferol binds to vitamin D receptors and modulates gene expression. This leads to an increase in serum calcium concentrations by increasing intestinal absorption of phosphorus and calcium, promoting distal renal tubular reabsorption of calcium and increasing osteoclastic resorption. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C48194" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C48194" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000039734 |
|
| altLabel |
Calciol 9,10-secocholesta-5,7,10(19)-trien-3-beta-ol (3beta,5Z,7E)-9,10-secocholesta-5,7,10(19)-trien-3-ol delsterol 9,10-secocholesta-5,7,10(19)-trien-3-ol Vitamin D3 |
|
| CAS Registry |
67-97-0 |
|
| Component of |
http://purl.bioontology.org/ontology/PDQ/CDR0000042823 http://purl.bioontology.org/ontology/PDQ/CDR0000420969 http://purl.bioontology.org/ontology/PDQ/CDR0000038395 http://purl.bioontology.org/ontology/PDQ/CDR0000038392 http://purl.bioontology.org/ontology/PDQ/CDR0000256446 http://purl.bioontology.org/ontology/PDQ/CDR0000038394 http://purl.bioontology.org/ontology/PDQ/CDR0000038391 http://purl.bioontology.org/ontology/PDQ/CDR0000038393 |
|
| cui |
C4721749 C0008318 |
|
| Date last modified |
2017-11-03 |
|
| definition |
A steroid hormone produced in the skin when exposed to ultraviolet light or obtained from dietary sources. The active form of cholecalciferol, 1,25-dihydroxycholecalciferol (calcitriol) plays an important role in maintaining blood calcium and phosphorus levels and mineralization of bone. The activated form of cholecalciferol binds to vitamin D receptors and modulates gene expression. This leads to an increase in serum calcium concentrations by increasing intestinal absorption of phosphorus and calcium, promoting distal renal tubular reabsorption of calcium and increasing osteoclastic resorption. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C48194" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C48194" NCI Thesaurus) |
|
| Legacy PDQ ID |
2396 |
|
| NCI ID |
C48194 |
|
| notation |
CDR0000039734 |
|
| NSC Code |
375571 |
|
| ORIG STY |
Drug/agent |
|
| prefLabel |
cholecalciferol |
|
| tui |
T109 T127 T121 |