loading...| Preferred Name | dactinomycin | |
| Synonyms |
actinomycin IV actinomycin-C1 AD Cosmegen actinomycin-D ACT-D 2-bis[cyclo(N-methyl-L-valyl-sarcosyl-L-prolyl-D-valyl-L-threonyl)]-1,9 dimethyl-4,6 3H-phenoxazinone-3 actinomycin D actinomycin I1 meractinomycin dactinomycine actinomycin C1 actinomycin X 1 DACT Lyovac Cosmegen actinomycin-[thr-val-pro-sar-meval] |
|
| Definitions |
A chromopeptide antineoplastic antibiotic isolated from the bacterium Streptomyces parvulus. Dactinomycin intercalates between adjacent guanine-cytosine base pairs, blocking the transcription of DNA by RNA polymerase; it also causes single-strand DNA breaks, possibly via a free-radical intermediate or an interaction with topoisomerase II. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C412" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C412" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000039675 |
|
| altLabel |
actinomycin IV actinomycin-C1 AD Cosmegen actinomycin-D ACT-D 2-bis[cyclo(N-methyl-L-valyl-sarcosyl-L-prolyl-D-valyl-L-threonyl)]-1,9 dimethyl-4,6 3H-phenoxazinone-3 actinomycin D actinomycin I1 meractinomycin dactinomycine actinomycin C1 actinomycin X 1 DACT Lyovac Cosmegen actinomycin-[thr-val-pro-sar-meval] |
|
| CAS Registry |
50-76-0 |
|
| Component of |
http://purl.bioontology.org/ontology/PDQ/CDR0000037848 http://purl.bioontology.org/ontology/PDQ/CDR0000039351 http://purl.bioontology.org/ontology/PDQ/CDR0000040284 http://purl.bioontology.org/ontology/PDQ/CDR0000039611 http://purl.bioontology.org/ontology/PDQ/CDR0000039642 http://purl.bioontology.org/ontology/PDQ/CDR0000041736 http://purl.bioontology.org/ontology/PDQ/CDR0000039693 http://purl.bioontology.org/ontology/PDQ/CDR0000040804 http://purl.bioontology.org/ontology/PDQ/CDR0000041051 http://purl.bioontology.org/ontology/PDQ/CDR0000040864 http://purl.bioontology.org/ontology/PDQ/CDR0000039584 http://purl.bioontology.org/ontology/PDQ/CDR0000040339 http://purl.bioontology.org/ontology/PDQ/CDR0000041130 http://purl.bioontology.org/ontology/PDQ/CDR0000041504 http://purl.bioontology.org/ontology/PDQ/CDR0000041694 http://purl.bioontology.org/ontology/PDQ/CDR0000038851 http://purl.bioontology.org/ontology/PDQ/CDR0000041050 http://purl.bioontology.org/ontology/PDQ/CDR0000040801 http://purl.bioontology.org/ontology/PDQ/CDR0000371722 http://purl.bioontology.org/ontology/PDQ/CDR0000040338 http://purl.bioontology.org/ontology/PDQ/CDR0000371721 http://purl.bioontology.org/ontology/PDQ/CDR0000039700 http://purl.bioontology.org/ontology/PDQ/CDR0000041222 http://purl.bioontology.org/ontology/PDQ/CDR0000334902 http://purl.bioontology.org/ontology/PDQ/CDR0000040949 http://purl.bioontology.org/ontology/PDQ/CDR0000040409 http://purl.bioontology.org/ontology/PDQ/CDR0000040314 http://purl.bioontology.org/ontology/PDQ/CDR0000039612 http://purl.bioontology.org/ontology/PDQ/CDR0000041129 |
|
| cui |
C0701095 C0010934 |
|
| Date last modified |
2012-03-15 |
|
| definition |
A chromopeptide antineoplastic antibiotic isolated from the bacterium Streptomyces parvulus. Dactinomycin intercalates between adjacent guanine-cytosine base pairs, blocking the transcription of DNA by RNA polymerase; it also causes single-strand DNA breaks, possibly via a free-radical intermediate or an interaction with topoisomerase II. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C412" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C412" NCI Thesaurus) |
|
| IND Code |
928 |
|
| Legacy PDQ ID |
233 |
|
| LT |
TRD |
|
| NCI ID |
C412 |
|
| notation |
CDR0000039675 |
|
| NSC Code |
3053 |
|
| ORIG STY |
Drug/agent |
|
| prefLabel |
dactinomycin |
|
| tui |
T195 T116 |