loading...| Preferred Name |
pyrazofurin |
|
| Synonyms |
pyrazole, -3-carboxamide, 4-Hydroxy-5-beta-L-ribofuranosyl |
|
| Definitions |
A nucleoside analog. Pyrazofurin potently inhibits orotidine 5'-monophosphate (OMP) decarboxylase, thereby interfering with de novo synthesis of uridine nucleotides and resulting in cytotoxicity. This agent also causes a rapid depletion of the pyrimidine deoxynucleotide pool, thereby inhibiting DNA synthesis and cell replication. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1208" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C1208" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000039575 |
|
| altLabel |
pyrazole, -3-carboxamide, 4-Hydroxy-5-beta-L-ribofuranosyl 47599 pyrazomycin 4-hydroxy-3-beta-D-ribofuranosylpyrazole-5-carboxamide pirazofurin compound 47599 beta-pyrazomycin |
|
| CAS Registry |
30868-30-5 |
|
| cui |
C1524065 C0072661 |
|
| Date last modified |
2006-12-15 |
|
| definition |
A nucleoside analog. Pyrazofurin potently inhibits orotidine 5'-monophosphate (OMP) decarboxylase, thereby interfering with de novo synthesis of uridine nucleotides and resulting in cytotoxicity. This agent also causes a rapid depletion of the pyrimidine deoxynucleotide pool, thereby inhibiting DNA synthesis and cell replication. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1208" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C1208" NCI Thesaurus) |
|
| IND Code |
12100 |
|
| Legacy PDQ ID |
2230 |
|
| NCI ID |
C1208 |
|
| notation |
CDR0000039575 |
|
| NSC Code |
143095 |
|
| ORIG STY |
Drug/agent |
|
| prefLabel |
pyrazofurin |
|
| tui |
T114 T121 |