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Physician Data Query
| Preferred Name | lithium carbonate | |
| Synonyms |
Lithium Lithane Lithotabs Lithonate Eskalith Lithobid |
|
| Definitions |
The carbonate salt of lithium, a soft alkali metal, with antimanic and hematopoietic activities. Lithium interferes with transmembrane sodium exchange in nerve cells by affecting sodium, potassium-stimulated adenosine triphosphatase (Na+, K+-ATPase); alters the release of neurotransmitters; affects cyclic adenosine monophosphate (cAMP) concentrations; and blocks inositol metabolism resulting in depletion of cellular inositol and inhibition of phospholipase C-mediated signal transduction. The exact mechanism through which lithium exerts its mood-stabilizing effect has not been established. In addition, lithium stimulates granulocytopoiesis and appears to increase the level of pluripotent hematopoietic stem cells by stimulating the release of hematopoietic cytokines and/or directly acting on hematopoietic stemcells. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1318" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C1318" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000039491 |
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| altLabel |
Lithium Lithane Lithotabs Lithonate Eskalith Lithobid
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|
| cui |
C0700752 C0700750 C0023870 C0700189 C0700751 C0085217 C0700753
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|
| Date last modified |
2008-02-15
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|
| definition |
The carbonate salt of lithium, a soft alkali metal, with antimanic and hematopoietic activities. Lithium interferes with transmembrane sodium exchange in nerve cells by affecting sodium, potassium-stimulated adenosine triphosphatase (Na+, K+-ATPase); alters the release of neurotransmitters; affects cyclic adenosine monophosphate (cAMP) concentrations; and blocks inositol metabolism resulting in depletion of cellular inositol and inhibition of phospholipase C-mediated signal transduction. The exact mechanism through which lithium exerts its mood-stabilizing effect has not been established. In addition, lithium stimulates granulocytopoiesis and appears to increase the level of pluripotent hematopoietic stem cells by stimulating the release of hematopoietic cytokines and/or directly acting on hematopoietic stemcells. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1318" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C1318" NCI Thesaurus)
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| Legacy PDQ ID |
2124
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|
| LT |
TRD
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| NCI ID |
C1318
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|
| notation |
CDR0000039491
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| ORIG STY |
Drug/agent
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|
| prefLabel |
lithium carbonate
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|
| tui |
T197 T109 T196 T121
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