loading...| Preferred Name | indomethacin | |
| Synonyms |
1-(4-chlorobenzoyl)-5-methoxy- 2-methyl-1-H-indole-3-acetic acid Indometacin Indocin INDO |
|
| Definitions |
A synthetic nonsteroidal indole derivative with anti-inflammatory activity and chemopreventive properties. As a nonsteroidal anti-inflammatory drug (NSAID), indomethacin inhibits the enzyme cyclooxygenase, thereby preventing cyclooxygenase-mediated DNA adduct formation by heterocyclic aromatic amines. This agent also may inhibit the expression of multidrug-resistant protein type 1, resulting in increased efficacies of some antineoplastic agents in treating multi-drug resistant tumors. In addition, indomethacin activates phosphatases that inhibit the migration and proliferation of cancer cells and downregulates survivin, which may result in tumor cell apoptosis. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C576" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C576" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000039489 |
|
| altLabel |
1-(4-chlorobenzoyl)-5-methoxy- 2-methyl-1-H-indole-3-acetic acid Indometacin Indocin INDO |
|
| CAS Registry |
53-86-1 |
|
| Component of |
http://purl.bioontology.org/ontology/PDQ/CDR0000039081 http://purl.bioontology.org/ontology/PDQ/CDR0000042558 http://purl.bioontology.org/ontology/PDQ/CDR0000041251 http://purl.bioontology.org/ontology/PDQ/CDR0000042188 http://purl.bioontology.org/ontology/PDQ/CDR0000041944 |
|
| cui |
C0021246 C0700798 |
|
| Date last modified |
2006-08-28 |
|
| definition |
A synthetic nonsteroidal indole derivative with anti-inflammatory activity and chemopreventive properties. As a nonsteroidal anti-inflammatory drug (NSAID), indomethacin inhibits the enzyme cyclooxygenase, thereby preventing cyclooxygenase-mediated DNA adduct formation by heterocyclic aromatic amines. This agent also may inhibit the expression of multidrug-resistant protein type 1, resulting in increased efficacies of some antineoplastic agents in treating multi-drug resistant tumors. In addition, indomethacin activates phosphatases that inhibit the migration and proliferation of cancer cells and downregulates survivin, which may result in tumor cell apoptosis. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C576" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C576" NCI Thesaurus) |
|
| Legacy PDQ ID |
2122 |
|
| LT |
TRD |
|
| NCI ID |
C576 |
|
| notation |
CDR0000039489 |
|
| NSC Code |
77541 |
|
| ORIG STY |
Drug/agent |
|
| prefLabel |
indomethacin |
|
| tui |
T109 T121 |