loading...| Preferred Name |
levothyroxine sodium |
|
| Synonyms |
Synthroid |
|
| Definitions |
The sodium salt of levothyroxine, a synthetic levoisomer of thyroxine (T4) that is similar to the endogenous hormone produced by the thyroid gland. In peripheral tissues, levothyroxine is deiodinated by 5'-deiodinase to form triiodothyronine (T3). T3 enters the cell and binds to nuclear thyroid hormone receptors; the activated hormone-receptor complex in turn triggers gene expression and produces proteins required in the regulation of cellular respiration; thermogenesis; cellular growth and differentiation; and the metabolism of proteins, carbohydrates and lipids. T3 also exhibits cardiostimulatory effects. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C888" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C888" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000039298 |
|
| altLabel |
Synthroid |
|
| cui |
C0079691 C0728762 |
|
| Date last modified |
2015-10-19 |
|
| definition |
The sodium salt of levothyroxine, a synthetic levoisomer of thyroxine (T4) that is similar to the endogenous hormone produced by the thyroid gland. In peripheral tissues, levothyroxine is deiodinated by 5'-deiodinase to form triiodothyronine (T3). T3 enters the cell and binds to nuclear thyroid hormone receptors; the activated hormone-receptor complex in turn triggers gene expression and produces proteins required in the regulation of cellular respiration; thermogenesis; cellular growth and differentiation; and the metabolism of proteins, carbohydrates and lipids. T3 also exhibits cardiostimulatory effects. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C888" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C888" NCI Thesaurus) |
|
| Legacy PDQ ID |
1931 |
|
| LT |
TRD |
|
| NCI ID |
C888 |
|
| notation |
CDR0000039298 |
|
| ORIG STY |
Drug/agent |
|
| prefLabel |
levothyroxine sodium |
|
| tui |
T125 T116 T121 |