Physician Data Query

Last uploaded: August 28, 2024
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Preferred Name

propylthiouracil
Synonyms

6-Propyl-2-Thiouracil
Definitions

A thiourea derivative with antithyroid property. Propylthiouracil (PTU) interferes with the oxidation of iodine possibly by interaction with peroxidase or a peroxidase-mediated complex reaction, thereby inhibiting synthesis of thyroid hormones tri-iodothyronine (T3) and thyroxine (T4). In addition, this agent inhibits the Type I 5'-deiodinase (D1), an enzyme involved in the peripheral conversion of thyroxine to tri-iodothyronine. This results in decreased plasma triodothyronine concentrations and decreased entrance of thyroxine into cells thereby reducing thyroid hormone activity. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C781" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C781" NCI Thesaurus)
ID

http://purl.bioontology.org/ontology/PDQ/CDR0000039288
altLabel

6-Propyl-2-Thiouracil
CAS Registry

51-52-5
cui

C0033511
definition

A thiourea derivative with antithyroid property. Propylthiouracil (PTU) interferes with the oxidation of iodine possibly by interaction with peroxidase or a peroxidase-mediated complex reaction, thereby inhibiting synthesis of thyroid hormones tri-iodothyronine (T3) and thyroxine (T4). In addition, this agent inhibits the Type I 5'-deiodinase (D1), an enzyme involved in the peripheral conversion of thyroxine to tri-iodothyronine. This results in decreased plasma triodothyronine concentrations and decreased entrance of thyroxine into cells thereby reducing thyroid hormone activity. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C781" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C781" NCI Thesaurus)
Legacy PDQ ID

1921
NCI ID

C781
notation

CDR0000039288
NSC Code

70461
ORIG STY

Drug/agent
prefLabel

propylthiouracil
tui

T114

T121
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Mapping To Ontology Source
http://purl.bioontology.org/ontology/SCTSPA/387203007 SCTSPA CUI
http://purl.bioontology.org/ontology/NDDF/002137 NDDF CUI
http://purl.bioontology.org/ontology/ATC/H03BA02 ATC CUI
http://purl.bioontology.org/ontology/VANDF/4017432 VANDF CUI
http://purl.bioontology.org/ontology/SNMI/C-A1870 SNMI CUI
http://purl.bioontology.org/ontology/RXNORM/8794 RXNORM CUI
http://purl.bioontology.org/ontology/MSHFRE/D011441 MSHFRE CUI
http://purl.bioontology.org/ontology/SNOMEDCT/3814009 SNOMEDCT CUI
http://purl.bioontology.org/ontology/LNC/LP17868-8 LOINC CUI
http://purl.bioontology.org/ontology/LNC/MTHU012366 LOINC CUI
http://purl.bioontology.org/ontology/RCD/fa3.. RCD CUI
http://purl.bioontology.org/ontology/NDFRT/N0000006787 NDFRT CUI
http://purl.bioontology.org/ontology/SNOMEDCT/387203007 SNOMEDCT CUI
http://purl.bioontology.org/ontology/MESH/D011441 MESH CUI
http://purl.bioontology.org/ontology/NDFRT/N0000145820 NDFRT CUI
http://purl.bioontology.org/ontology/SCTSPA/3814009 SCTSPA CUI
http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000145820 ODAE LOOM
rgo:15239 GAMUTS LOOM
http://purl.bioontology.org/ontology/NDDF/002137 NDDF LOOM
http://purl.bioontology.org/ontology/ATC/H03BA02 ATC LOOM
http://purl.bioontology.org/ontology/VANDF/4017432 VANDF LOOM
http://purl.obolibrary.org/obo/OMIT_0012388 OMIT LOOM
http://purl.obolibrary.org/obo/NCIT_C781 BERO LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D011441 RH-MESH LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#10209 OCHV LOOM
http://purl.bioontology.org/ontology/RXNORM/8794 RXNORM LOOM
http://purl.obolibrary.org/obo/MESH_D011441 BERO LOOM
http://stirdf.jst.go.jp/id/200907015853806444 IOBC LOOM
http://purl.bioontology.org/ontology/HOIP/HOIP_0005148 HOIP LOOM
http://purl.obolibrary.org/obo/TXPO_0005148 TXPO LOOM
http://www.drugbank.ca/drugs/DB00550 FTC LOOM
http://purl.bioontology.org/ontology/LNC/LP17868-8 LOINC LOOM
http://id.nlm.nih.gov/mesh/D011441 MDM LOOM
http://purl.bioontology.org/ontology/LNC/MTHU012366 LOINC LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D03.383.742.698.875.842.708 RH-MESH LOOM
http://www.co-ode.org/ontologies/galen#Propylthiouracil GALEN LOOM
http://purl.jp/bio/4/id/200906048187581078 IOBC LOOM
http://www.phoc.org.cn/pmo/class/PMO_00018465 PMAPP-PMO LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/387203007 SNOMEDCT LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0033511 OCHV LOOM
http://purl.bioontology.org/ontology/MESH/D011441 MESH LOOM
https://go.drugbank.com/drugs/DB00550 MDM LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C781 NCIT LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000145820 NDFRT LOOM