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Physician Data Query
| Preferred Name | ethinyl estradiol | |
| Synonyms |
Eticylol Diogyn E Lynoral Feminone Inestra Orestralyn ethinylestradiol (17alpha)-19-norpregna-1,3,5(10)-trien-20-yne-3,17-diol EE Ethinoral Estinyl |
|
| Definitions |
A semisynthetic estrogen. Ethinyl estradiol binds to the estrogen receptor complex and enters the nucleus, activating DNA transcription of genes involved in estrogenic cellular responses. This agent also inhibits 5-alpha reductase in epididymal tissue, which lowers testosterone levels and may delay progression of prostatic cancer. In addition to its antineoplastic effects, ethinyl estradiol protects against osteoporosis. In animal models, short-term therapy with this agent has been shown to provide long-term protection against breast cancer, mimicking the antitumor effects of pregnancy. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C486" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C486" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000039238 |
|
| altLabel |
Eticylol Diogyn E Lynoral Feminone Inestra Orestralyn ethinylestradiol (17alpha)-19-norpregna-1,3,5(10)-trien-20-yne-3,17-diol EE Ethinoral Estinyl
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| CAS Registry |
57-63-6
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| Component of | ||
| cui |
C0699364 C0699363 C0699362 C0699366 C0699367 C0015011 C0699365 C0700721 C0699368
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| Date last modified |
2006-08-02
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|
| definition |
A semisynthetic estrogen. Ethinyl estradiol binds to the estrogen receptor complex and enters the nucleus, activating DNA transcription of genes involved in estrogenic cellular responses. This agent also inhibits 5-alpha reductase in epididymal tissue, which lowers testosterone levels and may delay progression of prostatic cancer. In addition to its antineoplastic effects, ethinyl estradiol protects against osteoporosis. In animal models, short-term therapy with this agent has been shown to provide long-term protection against breast cancer, mimicking the antitumor effects of pregnancy. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C486" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C486" NCI Thesaurus)
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| IND Code |
7259
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|
| Legacy PDQ ID |
1860
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|
| LT |
TRD
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|
| NCI ID |
C486
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|
| notation |
CDR0000039238
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| NSC Code |
10973
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| ORIG STY |
Drug/agent
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|
| prefLabel |
ethinyl estradiol
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|
| tui |
T125 T109 T121
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