loading...| Preferred Name | duborimycin | |
| Synonyms |
Duborimycine, Hydrochloride 13-Hydroxydaunomycin Daunomycinol Duborimycin Hydrochloride Daunomycinol HCl Duborimycine 5,12-Naphthacenedione, 10-[(3-amino-2,3,6-trideoxy-.alpha.-L-lyxo-hexopyranosyl)oxy]-7,8, 9,10-tetrahydro-6,8,11-trihydroxy-8-(1-hydroxyethyl)-1-methoxy-, (8S-cis)-, hydrochloride Daunorubicineal |
|
| Definitions |
An anthracycline antineoplastic antibiotic with therapeutic effects similar to those of doxorubicin. Duborimycin exhibits cytotoxic activity through topoisomerase-mediated interaction with DNA, thereby inhibiting DNA replication and repair and RNA and protein synthesis. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1062" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C1062" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000039228 |
|
| altLabel |
Duborimycine, Hydrochloride 13-Hydroxydaunomycin Daunomycinol Duborimycin Hydrochloride Daunomycinol HCl Duborimycine 5,12-Naphthacenedione, 10-[(3-amino-2,3,6-trideoxy-.alpha.-L-lyxo-hexopyranosyl)oxy]-7,8, 9,10-tetrahydro-6,8,11-trihydroxy-8-(1-hydroxyethyl)-1-methoxy-, (8S-cis)-, hydrochloride Daunorubicineal |
|
| CAS Registry |
28008-55-1 |
|
| cui |
C0057159 C0969848 |
|
| Date last modified |
2006-12-12 |
|
| definition |
An anthracycline antineoplastic antibiotic with therapeutic effects similar to those of doxorubicin. Duborimycin exhibits cytotoxic activity through topoisomerase-mediated interaction with DNA, thereby inhibiting DNA replication and repair and RNA and protein synthesis. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1062" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C1062" NCI Thesaurus) |
|
| Legacy PDQ ID |
1850 |
|
| NCI ID |
C1062 |
|
| notation |
CDR0000039228 |
|
| NSC Code |
180510 |
|
| ORIG STY |
Drug/agent |
|
| prefLabel |
duborimycin |
|
| tui |
T109 T195 T121 |
| Delete | Mapping To | Ontology | Source |
|---|---|---|---|
| http://purl.bioontology.org/ontology/MESH/C000847 | MESH | CUI | |
| http://purl.bioontology.org/ontology/MESH/C000847 | MESH | CUI | |
| http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1062 | NCIT | LOOM | |
| http://purl.obolibrary.org/obo/NCIT_C1062 | BERO | LOOM |