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Physician Data Query
| Preferred Name | dianhydrogalactitol | |
| Synonyms |
DAG dulcitol diepoxide diepoxygalactitol galactitol, 1,2:5,6-dianhydro- (8CI 9CI) dianhydrodulcitol 1,2:5,6-dianhydrodulcitol 1,2:5,6 dianhydrogalactitol 1,2:5, 6-diepoxydulcitol galactitol diepoxydulcitol 1,2,5,6 dianhydrogalactitol |
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| Definitions |
A bifunctional hexitol derivative with potential antineoplastic activity. Dianhydrogalactitol alkylates and cross-links DNA via an epoxide group during all phases of the cell cycle, resulting in disruption of DNA function and cell cycle arrest. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C425" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C425" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000039215 |
|
| altLabel |
DAG dulcitol diepoxide diepoxygalactitol galactitol, 1,2:5,6-dianhydro- (8CI 9CI) dianhydrodulcitol 1,2:5,6-dianhydrodulcitol 1,2:5,6 dianhydrogalactitol 1,2:5, 6-diepoxydulcitol galactitol diepoxydulcitol 1,2,5,6 dianhydrogalactitol
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| CAS Registry |
23261-20-3
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|
| Component of |
http://purl.bioontology.org/ontology/PDQ/CDR0000039536 |
|
| cui |
C0011967 C0013283
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|
| definition |
A bifunctional hexitol derivative with potential antineoplastic activity. Dianhydrogalactitol alkylates and cross-links DNA via an epoxide group during all phases of the cell cycle, resulting in disruption of DNA function and cell cycle arrest. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C425" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C425" NCI Thesaurus)
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| IND Code |
10899
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|
| Legacy PDQ ID |
1837
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| NCI ID |
C425
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|
| notation |
CDR0000039215
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|
| NSC Code |
132313
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| ORIG STY |
Drug/agent
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|
| prefLabel |
dianhydrogalactitol
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|
| tui |
T109 T123 T121
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