Physician Data Query

Last uploaded: August 28, 2024
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Preferred Name

azathioprine sodium
Synonyms

Imuran

Imurel
Definitions

The sodium salt form of azathioprine, a pro-drug of purine analogue with immunosuppressive activity. Azathioprine is converted in vivo to its active metabolite 6-mercaptopurine (6-MP), which substitutes for the normal nucleoside and mistakenly gets incorporated into DNA sequences. This leads to inhibition of DNA, RNA, and protein synthesis. As a result, cell proliferation may be inhibited, particularly in lymphocytes and leukocytes. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C47961" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C47961" NCI Thesaurus)
ID

http://purl.bioontology.org/ontology/PDQ/CDR0000039157
altLabel

Imuran

Imurel
CAS Registry

55774-33-9
cui

C0887732

C0699279

C0699280
Date last modified

2017-10-23
definition

The sodium salt form of azathioprine, a pro-drug of purine analogue with immunosuppressive activity. Azathioprine is converted in vivo to its active metabolite 6-mercaptopurine (6-MP), which substitutes for the normal nucleoside and mistakenly gets incorporated into DNA sequences. This leads to inhibition of DNA, RNA, and protein synthesis. As a result, cell proliferation may be inhibited, particularly in lymphocytes and leukocytes. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C47961" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C47961" NCI Thesaurus)
Legacy PDQ ID

1777
LT

TRD
NCI ID

C47961
notation

CDR0000039157
NSC Code

39084
ORIG STY

Drug/agent
prefLabel

azathioprine sodium
tui

T109

T131

T121
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