loading...| Preferred Name |
ziv-aflibercept |
|
| Synonyms |
Aflibercept |
|
| Definitions |
A protein comprised of segments of the extracellular domains of humanvascular endothelial growth factor receptors 1 (VEGFR1) and 2 (VEGFR2)fused to the constant region (Fc) of human IgG1 with potentialantiangiogenic activity. Afilbercept, functioning as a soluble decoyreceptor, binds to pro-angiogenic vascular endothelial growth factors(VEGFs), thereby preventing VEGFs from binding to their cell receptors.Disruption of the binding of VEGFs to their cell receptors may result inthe inhibition of tumor angiogenesis, metastasis, and ultimately tumorregression. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C2682" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C2682" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000038652 |
|
| altLabel |
Aflibercept VEGF Trap vascular endothelial growth factor trap aflibercept Zaltrap VEGF Trap R1R2 |
|
| cui |
C3485624 C1134659 C3485619 |
|
| Date last modified |
2012-08-05 |
|
| definition |
A protein comprised of segments of the extracellular domains of humanvascular endothelial growth factor receptors 1 (VEGFR1) and 2 (VEGFR2)fused to the constant region (Fc) of human IgG1 with potentialantiangiogenic activity. Afilbercept, functioning as a soluble decoyreceptor, binds to pro-angiogenic vascular endothelial growth factors(VEGFs), thereby preventing VEGFs from binding to their cell receptors.Disruption of the binding of VEGFs to their cell receptors may result inthe inhibition of tumor angiogenesis, metastasis, and ultimately tumorregression. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C2682" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C2682" NCI Thesaurus) |
|
| Legacy PDQ ID |
11298 |
|
| LT |
TRD |
|
| NCI ID |
C2682 |
|
| notation |
CDR0000038652 |
|
| ORIG STY |
Drug/agent |
|
| prefLabel |
ziv-aflibercept |
|
| tui |
T109 T116 T129 T121 |