loading...| Preferred Name |
liposomal daunorubicin citrate |
|
| Synonyms |
liposomal daunorubicin |
|
| Definitions |
A liposome-encapsulated form of the citrate salt of the anthracycline antineoplastic antibiotic daunorubicin. Daunorubicin intercalates into DNA and interacts with topoisomerase II, thereby inhibiting DNA replication and repair and RNA and protein synthesis. Liposomal delivery of doxorubicin citrate improves drug penetration into tumors and decreases drug clearance, thereby increasing the duration of therapeutic drug effects. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C2213" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C2213" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000037796 |
|
| altLabel |
liposomal daunorubicin DaunoXome daunorubicin liposomal |
|
| Component of | ||
| cui |
C0592528 C0724567 C0717668 |
|
| Date last modified |
2006-07-20 |
|
| definition |
A liposome-encapsulated form of the citrate salt of the anthracycline antineoplastic antibiotic daunorubicin. Daunorubicin intercalates into DNA and interacts with topoisomerase II, thereby inhibiting DNA replication and repair and RNA and protein synthesis. Liposomal delivery of doxorubicin citrate improves drug penetration into tumors and decreases drug clearance, thereby increasing the duration of therapeutic drug effects. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C2213" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C2213" NCI Thesaurus) |
|
| Legacy PDQ ID |
10155 |
|
| LT |
TRD |
|
| NCI ID |
C2213 |
|
| notation |
CDR0000037796 |
|
| ORIG STY |
Drug/agent |
|
| prefLabel |
liposomal daunorubicin citrate |
|
| tui |
T109 T195 T121 |