loading...| Preferred Name | Sipuleucel-T | |
| Synonyms |
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| Definitions |
A cell-based vaccine composed of autologous antigen-presenting peripheral blood mononuclear cells (enriched for a dendritic cell fraction) that have been exposed to a recombinant protein consisting of granulocyte-macrophage colony-stimulating factor (GM-CSF) fused to prostatic-acid phosphatase (PAP), a protein expressed by prostate cancer cells. Upon administration, the vaccine may stimulate an antitumor T-cell response against tumor cells expressing PAP. (NCI05)/NCI-GLOSS Definition: A drug used to treat prostate cancer that has spread. It is made from immune system cells collected from a patient with prostate cancer. The cells are treated with a protein that is made by combining a protein found on prostate cancer cells with a growth factor. When the cells are injected back into the patient, they may stimulate T cells to kill prostate cancer cells. Provenge is a type of vaccine and a type of cellular adoptive immunotherapy. |
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| ID |
http://www.semanticweb.org/ontologies/2018/1/ProstateCancer.owl#Sipuleucel-T |
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| definition |
A cell-based vaccine composed of autologous antigen-presenting peripheral blood mononuclear cells (enriched for a dendritic cell fraction) that have been exposed to a recombinant protein consisting of granulocyte-macrophage colony-stimulating factor (GM-CSF) fused to prostatic-acid phosphatase (PAP), a protein expressed by prostate cancer cells. Upon administration, the vaccine may stimulate an antitumor T-cell response against tumor cells expressing PAP. (NCI05)/NCI-GLOSS Definition: A drug used to treat prostate cancer that has spread. It is made from immune system cells collected from a patient with prostate cancer. The cells are treated with a protein that is made by combining a protein found on prostate cancer cells with a growth factor. When the cells are injected back into the patient, they may stimulate T cells to kill prostate cancer cells. Provenge is a type of vaccine and a type of cellular adoptive immunotherapy. |
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| label |
Sipuleucel-T |
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| prefixIRI |
ProstateCancer:Sipuleucel-T |
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| prefLabel |
Sipuleucel-T |
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| reference |
NCI Thesaurus Code:C1985 |
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| synonyms |
Sipuleucel-T SIPULEUCEL-T APC8015 Vaccine sipuleucel-T PA2024 (PAP/GM-CSF)-Loaded Dendritic Cell Vaccine/ APC8015 Provenge |
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| URL |
https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C1985 |
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| subClassOf |
http://www.semanticweb.org/ontologies/2018/1/ProstateCancer.owl#Chemotherapy |