Prostate Cancer Ontology

Last uploaded: June 6, 2023
Id http://www.semanticweb.org/ontologies/2018/1/ProstateCancer.owl#Docetaxel_regimen
http://www.semanticweb.org/ontologies/2018/1/ProstateCancer.owl#Docetaxel_regimen
Preferred Name

Docetaxel regimen

Definitions
A significant improvement in median survival of 2-2.5 months occurred with docetaxel-based chemotherapy|compared to mitoxantrone + prednisone therapy. The standard for first-line cytotoxic chemotherapy|is docetaxel using the same regimen as in the TAX 327 trial, that is, 75 mg/m2 3 weekly combined with|prednisone 5 mg BID, up to 10 cycles, and palliation is the main target.|The patients considered for docetaxel represent a heterogeneous population. Several poor|prognostic factors have been described, such as a PSA level > 114 ng/mL, PSA-DT < 55 days, or the presence|of visceral metastases. A better risk group definition has recently been presented, based on the TAX|327 study cohort. The predictive factors were visceral metastases, pain, anaemia (Hb < 13 g/dL), bone scan|progression, and prior estramustine before docetaxel. Patients were categorised into three risk groups: low risk|(0 or 1 factor), intermediate (2 factors) and high risk (3 or 4 factors), leading to three different lengths of median|OS: 25.7, 18.7 and 12.8 months, respectively. In addition, two independent studies have suggested that|improved survival can be predicted by C-reactive protein (CRP) levels < 8 mg/L (HR, 2.96). Age by|itself is not a contraindication to docetaxel.
Type http://www.w3.org/2002/07/owl#Class
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