loading...| Preferred Name |
Adriamycin |
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| Synonyms |
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| Definitions |
The hydrochloride salt of doxorubicin, an anthracycline antibiotic with antineoplastic activity. Doxorubicin, isolated from the bacterium Streptomyces peucetius var. caesius, is the hydroxylated congener of daunorubicin. Doxorubicin intercalates between base pairs in the DNA helix, thereby preventing DNA replication and ultimately inhibiting protein synthesis. Additionally, doxorubicin inhibits topoisomerase II which results in an increased and stabilized cleavable enzyme-DNA linked complex during DNA replication and subsequently prevents the ligation of the nucleotide strand after double-strand breakage. Doxorubicin also forms oxygen free radicals resulting in cytotoxicity secondary to lipid peroxidation of cell membrane lipids; the formation of oxygen free radicals also contributes to the toxicity of the anthracycline antibiotics, namely the cardiac and cutaneous vascular effects./NCI-GLOSS Definition: A drug that is used to treat many types of cancer and is being studied in the treatment of other types of cancer. Adriamycin PFS comes from the bacterium Streptomyces peucetius. It damages DNA and may kill cancer cells. It is a type of anthracycline antitumor antibiotic. |
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| ID |
http://www.semanticweb.org/ontologies/2018/1/ProstateCancer.owl#Adriamycin |
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| ChineseLabel |
阿霉素 |
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| definition |
The hydrochloride salt of doxorubicin, an anthracycline antibiotic with antineoplastic activity. Doxorubicin, isolated from the bacterium Streptomyces peucetius var. caesius, is the hydroxylated congener of daunorubicin. Doxorubicin intercalates between base pairs in the DNA helix, thereby preventing DNA replication and ultimately inhibiting protein synthesis. Additionally, doxorubicin inhibits topoisomerase II which results in an increased and stabilized cleavable enzyme-DNA linked complex during DNA replication and subsequently prevents the ligation of the nucleotide strand after double-strand breakage. Doxorubicin also forms oxygen free radicals resulting in cytotoxicity secondary to lipid peroxidation of cell membrane lipids; the formation of oxygen free radicals also contributes to the toxicity of the anthracycline antibiotics, namely the cardiac and cutaneous vascular effects./NCI-GLOSS Definition: A drug that is used to treat many types of cancer and is being studied in the treatment of other types of cancer. Adriamycin PFS comes from the bacterium Streptomyces peucetius. It damages DNA and may kill cancer cells. It is a type of anthracycline antitumor antibiotic. |
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| label |
Adriamycin |
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| prefixIRI |
ProstateCancer:Adriamycin |
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| prefLabel |
Adriamycin |
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| reference |
NCI Thesaurus Code:C1326 |
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| synonyms |
Doxorubicin hydrochloride 3-Hydroxyacetyldaunorubicin Hydrochloride L-Lyxo-hexopyranoside, hydroxydaunorubicin Adriamycin PFS ADRIAMYCIN, HYDROCHLORIDE doxorubicin hydrochloride 5,12-Naphthacenedione, Doxorubicin Hydrochloride 3b-glycol-1,2,3,4,6,11-hexahydro-3,5,12-trihydroxy-10-methoxy-6,11-dioxo-3-amino-2,3,6-trideoxy-alpha-, hydrochloride/ Rubex Doxorubicin.HCl/Doxorubin 10-[(3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihy DOXORUBICIN HYDROCHLORIDE Chloridrato de Doxorrubicina y-alpha-, hydrochloride 9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-, hydrochloride, (8S-cis)- (9CI) Adriblastine Adriamycine Farmiblastina 14-Hydroxydaunorubicin Hydrochloride Adriblastina Adriamycin RDF 5,12-Naphthacenedione, 10-[(3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy]-7,8, Adriamycin hydrochloride droxy-8-(hydroxyacetyl)-1-methoxy-,hydrochloride, (8S-cis)-(9CI) Adriamycin Hydrochloride ADM Adriacin Adriamycin Adrimedac DOX DOXO-CELL Doxolem FI 106 FI-106 Rubex |
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| URL |
https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C1326 |
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| subClassOf |
http://www.semanticweb.org/ontologies/2018/1/ProstateCancer.owl#Chemotherapy |