Placental Maternal Health Conditions

Last uploaded: January 13, 2020
Id http://pat.nichd.nih.gov/maternalconditions/C0001403
http://pat.nichd.nih.gov/maternalconditions/C0001403
Preferred Name

Addison's Disease

Definitions
[CSP Definition]: Disease characterized by hypotension, weight loss, anorexia, weakness, and sometimes a bronze-like melanotic hyperpigmentation of the skin; due to tuberculosis or autoimmune induced disease (hypofunction) of the adrenal glands that results in deficiency of aldosterone and cortisol. [HPO Definition]: Insufficient production of steroid hormones (primarily cortisol) by the adrenal glands as a result of a primary defect in the glands themselves. [HPO:probinson] [NICHD Definition]: The diminished production of adrenocortical hormones due to a pathologic process within the adrenal glands. [MSH Definition]: An adrenal disease characterized by the progressive destruction of the ADRENAL CORTEX, resulting in insufficient production of ALDOSTERONE and HYDROCORTISONE. Clinical symptoms include ANOREXIA; NAUSEA; WEIGHT LOSS; MUSCLE WEAKNESS; and HYPERPIGMENTATION of the SKIN due to increase in circulating levels of ACTH precursor hormone which stimulates MELANOCYTES. [NCIt Definition]: A long-standing and persistent diminished production of adrenocortical hormones due to a disorder originating within the adrenal glands. [GARD Definition]: Addison's disease is a condition that occurs when the adrenal glands do not produce enough of their hormones. This condition can be caused by damage to the adrenal glands, autoimmune conditions, and certain genetic conditions. Some of the symptoms include changes in blood pressure, chronic diarrhea, darkening of the skin, paleness, extreme weakness, fatigue, nausea and vomiting, salt craving, and weight loss. Treatment with replacement corticosteroids usually controls the symptoms. - this information is from GARD/ORDR/NCATS.
Synonyms
Primary Addisons Disease
Primary Adrenocortical Insufficiency
Primary Hypoadrenalism
Adrenocortical insufficiency chronic
Addison's Disease
Hypocortisolism
Primary Adrenocortical Failure
Classic Addisons Disease
Adrenal Insufficiency (Addison Disease)
Primary Adrenal Insufficiency
Chronic Primary Adrenal Insufficiency
Addisons Disease
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Type http://www.w3.org/2002/07/owl#Class
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