Orphanet Rare Disease Ontology

Last uploaded: July 3, 2024
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Preferred Name

Acute undifferentiated leukemia
Synonyms

Acute myeloid leukemia, minimal differentiation, FAB M0
Definitions

A rare acute leukemia of ambiguous lineage characterized by clonal proliferation of primitive hematopoietic cells, primarily in the bone marrow and blood, lacking lineage-specific markers and detectable genotypic alterations. The patients present with leukocytosis, anemia, variable platelet count and a variety of nonspecific symptoms related to ineffective hematopoesis (fatigue, bleeding and bruising, recurrent infections, bone pain) and/or extramedullary site involvement (lymphadenopathy, splenomegaly, hepatomegaly).
ID

http://www.orpha.net/ORDO/Orphanet_98835
alternative_term

Acute myeloid leukemia, minimal differentiation, FAB M0
definition

A rare acute leukemia of ambiguous lineage characterized by clonal proliferation of primitive hematopoietic cells, primarily in the bone marrow and blood, lacking lineage-specific markers and detectable genotypic alterations. The patients present with leukocytosis, anemia, variable platelet count and a variety of nonspecific symptoms related to ineffective hematopoesis (fatigue, bleeding and bruising, recurrent infections, bone pain) and/or extramedullary site involvement (lymphadenopathy, splenomegaly, hepatomegaly).
definition_citation

Orphanet
expertlink

https://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=en&Expert=98835
hasDbXref

ICD-11:2A60.30

UMLS:C0280141

OMIM:601626

MedDRA:10045516

ICD-10:C95.0
label

Acute undifferentiated leukemia
notation

ORPHA:98835
part_of

http://www.orpha.net/ORDO/Orphanet_86851
prefixIRI

ORDO:Orphanet_98835
prefLabel

Acute undifferentiated leukemia
treeView

http://www.orpha.net/ORDO/Orphanet_86851
subClassOf

http://www.orpha.net/ORDO/Orphanet_377788

http://www.orpha.net/ORDO/Orphanet_557493
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