Subacute myeloid leukemia

A rare myelodysplastic/myeloproliferative neoplasm characterized by peripheral blood leukocytosis due to increased numbers of morphologically dysplastic neutrophils and their precursors, hypercellular bone marrow with granulocytic proliferation and dysplasia (with or without dysplasia in the erythroid and megakaryocytic lineages), and prominent dysgranulopoiesis, but no or minimal absolute basophilia or monocytosis. Blasts account for less than 20% of leukocytes in the blood and bone marrow. BCR-ABL1 fusion is absent, as well as PDGFRA, PDGFRB or FGFR1 rearrangement, or PCM1-JAK2. Patients may present with signs and symptoms related to splenomegaly, anemia, or thrombocytopenia. Prognosis is generally poor.

http://www.orpha.net/ORDO/Orphanet_98824

Subacute myeloid leukemia

A rare myelodysplastic/myeloproliferative neoplasm characterized by peripheral blood leukocytosis due to increased numbers of morphologically dysplastic neutrophils and their precursors, hypercellular bone marrow with granulocytic proliferation and dysplasia (with or without dysplasia in the erythroid and megakaryocytic lineages), and prominent dysgranulopoiesis, but no or minimal absolute basophilia or monocytosis. Blasts account for less than 20% of leukocytes in the blood and bone marrow. BCR-ABL1 fusion is absent, as well as PDGFRA, PDGFRB or FGFR1 rearrangement, or PCM1-JAK2. Patients may present with signs and symptoms related to splenomegaly, anemia, or thrombocytopenia. Prognosis is generally poor.

Orphanet

https://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=en&Expert=98824

Adult

UMLS:C1292772

MeSH:D054438

ICD-10:C92.2

ICD-11:2A41

MedDRA:10054651

Atypical chronic myeloid leukemia

ORPHA:98824

http://www.orpha.net/ORDO/Orphanet_98275

ORDO:Orphanet_98824

Atypical chronic myeloid leukemia

Europe AND has_annual_incidence_range : <1 / 1 000 000

http://www.orpha.net/ORDO/Orphanet_98275

http://www.orpha.net/ORDO/Orphanet_377788

http://www.orpha.net/ORDO/Orphanet_557493