Orphanet Rare Disease Ontology

Last uploaded: December 4, 2024
Id http://www.orpha.net/ORDO/Orphanet_90281
http://www.orpha.net/ORDO/Orphanet_90281
Preferred Name

Discoid lupus erythematosus

Definitions
A rare form of chronic cutaneous lupus erythematosus characterized by erythematous, scaly papules and plaques preferentially occurring on sun-exposed skin areas (scalp, face, and ears) and exhibiting follicular plugging, pigmentary changes, and central atrophy, scarring, and telangiectasia. Skin biopsy shows a perivascular and periadnexal lymphocytic infiltrate and involvement of the dermoepidermal junction with thickening of the basement membrane and vacuolar degeneration of the basal cells. A small percentage of patients may develop systemic lupus erythematosus.
Type http://www.w3.org/2002/07/owl#Class
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