loading...| Preferred Name | Vinca-Domain Binding Agent | |
| Synonyms |
Vinca-Site Binding Agents |
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| Definitions |
Any of a class of anti-mitotic compounds that bind to the vinca site of the beta tubulin subunit, a region located within the middle domain of the tubulin structure and corresponding with a residue sequence approximating 177-215. The agent binds to the vinca site to produce a conformational change in the protofilament structure and at high concentrations, to induce the formation of spirals and crystal aggregates; these changes impair the polymerization of tubulin dimers and thereby, prevent the (source : ) |
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| ID |
http://doe-generated-ontology.com/OntoAD#C1883533 |
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| altLabel |
Vinca-Site Binding Agents |
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| definition |
Any of a class of anti-mitotic compounds that bind to the vinca site of the beta tubulin subunit, a region located within the middle domain of the tubulin structure and corresponding with a residue sequence approximating 177-215. The agent binds to the vinca site to produce a conformational change in the protofilament structure and at high concentrations, to induce the formation of spirals and crystal aggregates; these changes impair the polymerization of tubulin dimers and thereby, prevent the (source : ) |
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| hiddenLabel |
Vinca-DomainBindingAgent |
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| prefixIRI |
OntoAD:C1883533 |
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| prefLabel |
Vinca-Domain Binding Agent |
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| subClassOf |
| Delete | Mapping To | Ontology | Source |
|---|---|---|---|
| http://purl.obolibrary.org/obo/NCIT_C67422 | BERO | LOOM | |
| http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C67422 | NCIT | LOOM |