loading...| Preferred Name |
ESR1 protein, human |
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| Synonyms |
estrogen receptor 1, human |
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| Definitions |
Encoded by human ESR1 Gene (NR3 Family) as 2 alternative isoforms, Estrogen Receptor 1 is a ligand-activated nuclear hormone receptor transcription factor composed of an N-terminal transcription activation/modulation domain, a DNA-binding domain, and a C-terminal steroid-binding domain. ESR1 binds DNA as a homodimer or as a heterodimer with ESR2 and interacts with NCOA3, NCOA5, and NCOA6 coactivators. Hormone-ESR1 complexes appear to recognize discrete upstream target ERE DNA sequences to regula (source : ) |
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| ID |
http://doe-generated-ontology.com/OntoAD#C1521863 |
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| altLabel |
estrogen receptor 1, human Estrogen Receptor Estrogen Receptor 1 Estrogen Receptor Alpha estrogen receptor alpha, human ESR1 ER-Alpha Estradiol Receptor NR3A1 protein, human |
|
| definition |
Encoded by human ESR1 Gene (NR3 Family) as 2 alternative isoforms, Estrogen Receptor 1 is a ligand-activated nuclear hormone receptor transcription factor composed of an N-terminal transcription activation/modulation domain, a DNA-binding domain, and a C-terminal steroid-binding domain. ESR1 binds DNA as a homodimer or as a heterodimer with ESR2 and interacts with NCOA3, NCOA5, and NCOA6 coactivators. Hormone-ESR1 complexes appear to recognize discrete upstream target ERE DNA sequences to regula (source : ) |
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| gene_product_encoded_by_gene |
http://doe-generated-ontology.com/OntoAD#C0812327 http://doe-generated-ontology.com/OntoAD#C0017362 http://doe-generated-ontology.com/OntoAD#C1710463 http://doe-generated-ontology.com/OntoAD#C1335077 http://doe-generated-ontology.com/OntoAD#C1334396 |
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| gene_product_has_associated_anatomy | ||
| gene_product_has_biochemical_function |
http://doe-generated-ontology.com/OntoAD#C1336788 http://doe-generated-ontology.com/OntoAD#C0597357 http://doe-generated-ontology.com/OntoAD#C0040648 |
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| gene_product_plays_role_in_biological_process | ||
| hiddenLabel |
ESR1Protein,Human |
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| prefixIRI |
OntoAD:C1521863 |
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| prefLabel |
ESR1 protein, human |
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| subClassOf |
| Delete | Mapping To | Ontology | Source |
|---|---|---|---|
| http://purl.bioontology.org/ontology/MESH/C506487 | MESH | LOOM |