loading...| Preferred Name |
APP protein, human |
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| Synonyms |
Amyloid Beta-Peptide |
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| Definitions |
Encoded by human APP Gene (APP Family), Amyloid Beta A4 Protein Precursor is an N-/O-glycosylated sulfated metal ion-binding type I cell surface protein containing a BPTI protease inhibitor domain. Widely expressed APP is processed by secretases into soluble peptides, membrane-anchored fragments, plaque amyloid components, and cytotoxic fragments. Phosphorylation by Casein Kinases, CDC5, CDC2, and MAPK10 can affect processing, interaction with Fe65, and SHC binding. A kinesin I membrane receptor (source : ) |
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| ID |
http://doe-generated-ontology.com/OntoAD#C0611285 |
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| altLabel |
Amyloid Beta-Peptide Alzheimer's Disease Amyloid Protein Amyloid of Aging and Alzheimer Disease Protein Cerebralvascular Amyloid Peptide APPI protein, human peptidase nexin-II, human Alzheimer Disease 1 Protein amyloid beta (A4) precursor protein PN II PN2 APPI ABPP protease nexin 2, human Protease Nexin II CVAP Amyloid Beta A4 Protein Precursor Protease Nexin-II, Alzheimer Disease PreA4 |
|
| definition |
Encoded by human APP Gene (APP Family), Amyloid Beta A4 Protein Precursor is an N-/O-glycosylated sulfated metal ion-binding type I cell surface protein containing a BPTI protease inhibitor domain. Widely expressed APP is processed by secretases into soluble peptides, membrane-anchored fragments, plaque amyloid components, and cytotoxic fragments. Phosphorylation by Casein Kinases, CDC5, CDC2, and MAPK10 can affect processing, interaction with Fe65, and SHC binding. A kinesin I membrane receptor (source : ) |
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| gene_product_encoded_by_gene |
http://doe-generated-ontology.com/OntoAD#C1334396 |
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| gene_product_has_associated_anatomy | ||
| gene_product_has_biochemical_function | ||
| gene_product_has_organism_source | ||
| gene_product_malfunction_associated_with_disease | ||
| gene_product_plays_role_in_biological_process | ||
| hiddenLabel |
APPProtein,Human |
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| prefixIRI |
OntoAD:C0611285 |
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| prefLabel |
APP protein, human |
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| subClassOf |
| Delete | Mapping To | Ontology | Source |
|---|---|---|---|
| http://purl.bioontology.org/ontology/MESH/C545487 | MESH | LOOM | |
| http://phenomebrowser.net/ontologies/mesh/mesh.owl#C545487 | RH-MESH | LOOM |