loading...| Preferred Name |
Antineoplastic Agents, Alkylating |
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| Synonyms |
Antineoplastic Drugs, Alkylating Anticancéreux alcoylants Anticancéreux alkylants Chemotherapy Alkylators |
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| Definitions |
A class of drugs that differs from other alkylating agents used clinically in that they are monofunctional and thus unable to cross-link cellular macromolecules. Among their common properties are a requirement for metabolic activation to intermediates with antitumor efficacy and the presence in their chemical structures of N-methyl groups, that after metabolism, can covalently modify cellular DNA. The precise mechanisms by which each of these drugs acts to kill tumor cells are not completely und (source : MSH) |
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| ID |
http://doe-generated-ontology.com/OntoAD#C0282532 |
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| altLabel |
Antineoplastic Drugs, Alkylating Agents anticancéreux alkylants Antineoplastics, Alkylating ALKYLATING ANTINEOPL DRUGS Antinéoplasiques alkylants ANTINEOPLASTICS,ALKYLATING AGENTS Chemotherapy Alkylating Agents ALKYLATING AGENTS ANTINEOPL ALKYLATING ANTINEOPL Chemotherapy Alkylators Anticancéreux alkylants Anticancéreux alcoylants |
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| definition |
A class of drugs that differs from other alkylating agents used clinically in that they are monofunctional and thus unable to cross-link cellular macromolecules. Among their common properties are a requirement for metabolic activation to intermediates with antitumor efficacy and the presence in their chemical structures of N-methyl groups, that after metabolism, can covalently modify cellular DNA. The precise mechanisms by which each of these drugs acts to kill tumor cells are not completely und (source : MSH) |
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| hiddenLabel |
AntineoplasticAgents,Alkylating AntinéoplasiquesAlcoylants |
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| prefixIRI |
OntoAD:C0282532 |
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| prefLabel |
Antinéoplasiques alcoylants Antineoplastic Agents, Alkylating |
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| subClassOf |